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Shirley, MA 01464
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CA12 / Carbonic Anhydrase XII
carbonic anhydrase XII
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene.
| Gene Name: | carbonic anhydrase XII |
| Synonyms: | CA12, CA-XII, Carbonic anhydrase 12, Carbonic dehydratase, CAXII, HsT18816, Tumor antigen HOM-RCC-3.1.3, Carbonate dehydratase XII, Carbonic anhydrase XII |
| Target Sequences: | NM_001218 NP_001209.1 O43570 |
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