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C6orf134 / ATAT1
alpha tubulin acetyltransferase 1
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
| Gene Name: | alpha tubulin acetyltransferase 1 |
| Synonyms: | ATAT1, Alpha-TAT, Em:AB023049.7, MEC17, Nbla00487, C6orf134 |
| Target Sequences: | NM_024909 NP_079185.2 Q5SQI0 |
Publications (1)
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