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C1orf187 / DRAXIN

dorsal inhibitory axon guidance protein

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

Gene Name:	dorsal inhibitory axon guidance protein
Synonyms:	DRAXIN, AGPA3119, UNQ3119, C1orf187, Neucrin
Target Sequences:	Q8NBI3 Q8NBI3

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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