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C-TAK1 / MARK3
MAP/microtubule affinity-regulating kinase 3
MARK3, a MARK type protein kinase, was originally identified as a marker induced with DNA damaging agents. The protein contains a N-terminal kinase domain. It has been shown to bind and phosphorylate CDC25C and to regulate Ras signaling by phosphorylating the MAPK scaffold, KSR1. At least three mRNA transcripts have been reported -- 3.0-, 3.1-, and 3.8-kb. Loss of MARK3 has been associated with carcinogenesis in the pancreas.
| Gene Name: | MAP/microtubule affinity-regulating kinase 3 |
| Family/Subfamily: | Protein Kinase , MARK |
| Synonyms: | MARK3, C-TAK1, ELKL motif kinase 2, EMK2, Etk-1, KP78, PAR1A, Ser/Thr protein kinase PAR-1, Par-1a, CTAK1, EMK-2, Protein kinase STK10 |
| Target Sequences: | NM_002376 NP_002367.5 P27448 |
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