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BTK

Bruton agammaglobulinemia tyrosine kinase

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.

Gene Name: Bruton agammaglobulinemia tyrosine kinase
Family/Subfamily: Protein Kinase , BTK/TEC
Synonyms: BTK, AGMX1, AT, ATK, XLA, PSCTK1, B-cell progenitor kinase, BPK, Bruton tyrosine kinase, Tyrosine-protein kinase BTK, IMD1
Target Sequences: NM_000061 NP_000052.1 Q06187

Publications (1)

1
Therapeutics That Promote Sympathetic Reinnervation Modulate the Inflammatory Response After Myocardial Infarction. Joseph J Sepe, Ryan T Gardner, Matthew R Blake, Deja M Brooks, Melanie A Staffenson, Courtney B Betts, Sam Sivagnanam, William Larson, Sushil Kumar, Richard G Bayles, Haihong Jin, Michael S Cohen, Lisa M Coussens, Beth A Habecker. JACC. Basic to translational science. 2022 September;7:915-930. [Full Text Article] [PubMed:36317132] [PMC:PMC9617125] Related Antibodies: LS-C180161.

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Antibodies (94)
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BTK Antibody - Immunohistochemistry: BTK [p Tyr223] Antibody - IHC of BTK in kidney cancer xenograft using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BTK Rabbit anti-Human Polyclonal (pTyr223) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
BTK Antibody - Immunohistochemistry: BTK [p Tyr223] Antibody - IHC of BTK in kidney cancer xenograft using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BTK Rabbit anti-Human Polyclonal (pTyr223) (Biotin) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
BTK Antibody - Anti-BTK antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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BTK Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
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Yeast
6His, N-terminus
78.1 kD
1 mg/$1,607; 100 µg/$469; 20 µg/$349
BTK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
BTK Antibody - Immunohistochemistry of BTK in mouse brain tissue with BTK antibody at 5 µg/mL.
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BTK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1 mg/$460
BTK ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
BTK ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
BTK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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BTK Rabbit anti-Human Polyclonal (aa27-55) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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BTK Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
BTK Antibody - Immunohistochemistry of formalin-fixed paraffin-embedded (FFPE) mouse spleen using BTK antibody at dilution of 1:100 (40x magnification).
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BTK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
BTK Antibody - Immunofluorescent analysis of BTK (pY551) staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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BTK Rabbit anti-Human Polyclonal (pTyr551) Antibody
Mouse, Dog, Bovine, Rat, Human, Monkey
ICC, IF, IP, WB
Unconjugated
100 µl/$315
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BTK Rabbit anti-Human Polyclonal (aa209-239) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
BTK Antibody - Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (OTI3D11) Antibody
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BTK Antibody - IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (OTI3A2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BTK Antibody - IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (Carrier-free) (OTI3A2) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BTK Antibody - Western blot of recombinant BTK.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BTK Rabbit anti-Human Polyclonal (aa396-659) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
BTK Antibody - IHC of paraffin-embedded Kidney tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (OTI12D4) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BTK Antibody - IHC of paraffin-embedded Adenocarcinoma of ovary tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (OTI6H9) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BTK Antibody - IHC of paraffin-embedded Adenocarcinoma of ovary tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (Carrier-free) (OTI6H9) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BTK Antibody - IHC of paraffin-embedded Kidney tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (OTI1H7) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BTK Antibody - IHC of paraffin-embedded Kidney tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (Carrier-free) (OTI1H7) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BTK Antibody - IHC of paraffin-embedded colon tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (OTI15G8) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BTK Antibody - IHC of paraffin-embedded colon tissue using anti-BTK mouse monoclonal antibody. (Dilution 1:50).
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BTK Mouse anti-Human Monoclonal (Carrier-free) (OTI15G8) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Viewing 1-25 of 116 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).