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BTG1 is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia.
Gene Name: | B-cell translocation gene 1, anti-proliferative |
Synonyms: | BTG1, Protein BTG1 |
Target Sequences: | NM_001731 NP_001722.1 P62324 |
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