BRUCE / BIRC6

baculoviral IAP repeat containing 6

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

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Products

Proteins (2)

Type

Recombinant (2)

Target

BRUCE / BIRC6 (2)

Publications

No (2)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human BRUCE / BIRC6 Protein (Recombinant His, N-Terminal) (Arg4576-Leu4857) - LS-G25440

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

35.5 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human BRUCE / BIRC6 Protein (Recombinant GST, N-terminus) (aa31-140) - LS-G62948

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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