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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Additional Contact Details
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BRMS1
breast cancer metastasis suppressor 1
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
| Gene Name: | breast cancer metastasis suppressor 1 |
| Synonyms: | BRMS1, DKFZP564A063 |
| Target Sequences: | NM_001024957 NP_001020128.1 Q9HCU9 |
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