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Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Gene Name: | breast cancer metastasis suppressor 1 |
Synonyms: | BRMS1, DKFZP564A063 |
Target Sequences: | NM_001024957 NP_001020128.1 Q9HCU9 |
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