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Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.
Gene Name: | bromodomain, testis-specific |
Family/Subfamily: | Protein Kinase , BRD |
Synonyms: | BRDT, Cancer/testis antigen 9, Fsrg3, RING3-like protein, BRD6, Bromodomain, testis-specific, CT9, Testis-specific bromodomain |
Target Sequences: | NM_001726 NP_001717.3 Q58F21 |
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