BRD8

bromodomain containing 8

May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

BRD8 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human BRD8 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67597

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

135.2 kDa

Price:

20 µg/$1,107

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BRD8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107061

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

135.2 kDa

Price:

100 µg/$710

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Mouse BRD8 Protein (Recombinant His-T7) (aa797-951) - LS-G24716

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.2 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human BRD8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80250

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

135.2 kDa

Price:

20 µg/$215

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Human BRD8 Protein (Recombinant GST, N-terminus) (aa33-128) - LS-G61672

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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