BRD7

bromodomain containing 7

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

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Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

BRD7 (6)

Publications

No (6)

Tag

GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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BRD7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130129

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.7 kDa

Price:

100 µg/$494

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Human BRD7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89786

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.7 kDa

Price:

20 µg/$150

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Human BRD7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89788

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74 kDa

Price:

20 µg/$150

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BRD7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114363

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74 kDa

Price:

100 µg/$494

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Human BRD7 Protein (Recombinant GST) (Full Length) - LS-G33416

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

97.13 kDa

Price:

2 µg/$439

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Human BRD7 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71444

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74 kDa

Price:

20 µg/$1,107

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