BRD4

bromodomain containing 4

Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

BRD4 (3)

Publications

No (3)

Tag

10His, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human BRD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82668

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.3 kDa

Price:

20 µg/$215

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BRD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114040

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.3 kDa

Price:

100 µg/$710

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Human BRD4 Protein (Recombinant 10His, N-terminus) - LS-G146122

Source:

E. coli

Tag:

10His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49 kDa

Price:

10 µg/$289; 50 µg/$446

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