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BRCA1

breast cancer 1, early onset

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.

Gene Name: breast cancer 1, early onset
Synonyms: BRCA1, BROVCA1, BRCC1, Breast cancer 1, early onset, PPP1R53, PSCP, PNCA4, RING finger protein 53, RNF53, BRCAI, Breast cancer 1 early onset, IRIS
Target Sequences: NM_007294 NP_009225.1 P38398

Publications (4)

1
Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. Okada S, Ouchi T. The Journal of biological chemistry. 2003 278:2015-20. [PubMed:12427729]
2
ATM activation by ionizing radiation requires BRCA1-associated BAAT1. Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T. The Journal of biological chemistry. 2006 281:9710-8. [PubMed:16452482]
3
Identification and molecular characterization of a new member of the peritrophic membrane proteins from the meadow moth, loxostege sticticalis. Yin J, Wei ZJ, Li KB, Cao YZ, Guo W. International journal of biological sciences. 2010 6:491-8. [PubMed:20827401] [PMC:PMC2935671]
4
Assessing 'radiosensitivity' with kinetic profiles of -H2AX, 53BP1 and BRCA1 foci. Martin NT, Nahas SA, Tunuguntla R, Fike F, Gatti RA. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2011 101:35-8. (ICC; Human) [PubMed:21722985] [PMC:PMC3202034]
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Proteins (7)
Recombinant (7)
BRCA1 (7)
No (7)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
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His, N-terminus (1)
His-GST (1)
His-T7 (1)
Human (5)
Mouse (1)
Rat (1)
E. coli (5)
Wheat Germ Extract (2)
Purified (2)
BRCA1 Protein - Recombinant Breast Cancer Susceptibility Protein 1 By SDS-PAGE
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E. coli
His
9.0 kDa
10 µg/$300; 50 µg/$562; 100 µg/$897; 200 µg/$1,096; 1 mg/$2,284; 500 µg/$1,796; 5 mg/$3,921; 2 mg/$2,476
BRCA1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
BRCA1 Protein - Recombinant Breast Cancer Susceptibility Protein 1 By SDS-PAGE
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E. coli
His-GST
58.5 kDa
10 µg/$295; 50 µg/$527; 100 µg/$842; 200 µg/$1,042; 1 mg/$2,206; 500 µg/$1,724; 5 mg/$3,683; 2 mg/$2,397
BRCA1 Protein - Recombinant Breast Cancer Susceptibility Protein 1 By SDS-PAGE
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E. coli
His-T7
32.5 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
BRCA1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BRCA1 Protein - Recombinant Human BRCA1 Protein (His Tag)-Elabscience
Select
E. coli
His, N-terminus
28.8 kDa
20 µg/$270; 100 µg/$390
BRCA1 Protein - 12.5% SDS-PAGE of human BRCA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
33.1 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).