BRCA1

breast cancer 1, early onset

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.

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Products

Proteins (7)

Type

Recombinant (7)

Target

BRCA1 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His, N-terminus (1)

His-GST (1)

His-T7 (1)

Species

Human (5)

Mouse (1)

Rat (1)

Source

E. coli (5)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human BRCA1 Protein (Recombinant His) (aa19-83) - LS-G13740

Source:

E. coli

Tag:

His

Molecular Weight:

9.0 kDa

Price:

10 µg/$300; 50 µg/$562; 100 µg/$897; 200 µg/$1,096; 1 mg/$2,284; 500 µg/$1,796; 5 mg/$3,921; 2 mg/$2,476

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Human BRCA1 Protein (Recombinant 6His, N-terminus) (aa24-255) - LS-G57091

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Rat BRCA1 Protein (Recombinant His-GST) (aa1579-1811) - LS-G13742

Source:

E. coli

Tag:

His-GST

Molecular Weight:

58.5 kDa

Price:

10 µg/$295; 50 µg/$527; 100 µg/$842; 200 µg/$1,042; 1 mg/$2,206; 500 µg/$1,724; 5 mg/$3,683; 2 mg/$2,397

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Mouse BRCA1 Protein (Recombinant His-T7) (aa1524-1781) - LS-G13738

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.5 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human BRCA1 Protein (Recombinant GST, N-terminus) (aa1581-1670) - LS-G57920

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human BRCA1 Protein (Recombinant His, N-terminus) - LS-G145976

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

28.8 kDa

Price:

20 µg/$270; 100 µg/$390

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Human BRCA1 Protein (Recombinant GST) (Full Length) - LS-G27656

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

33.1 kDa

Price:

10 µg/$479; 25 µg/$670

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