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BMP1

bone morphogenetic protein 1

BMP1 encodes a Metallopeptidase M12A type protease that is comprised of an amino terminal signal peptide, prodomain and an astacin-like protease domain followed by CUB and EGF-like motifs. BMP1 protein has been shown to cleave chordin, the C-terminal propeptides of procollagen I, II, III and VII, pro-lysyl oxidase, probiglycan, and laminin-5, and its expression has been shown to induce cartilage and bone formation in vivo. At least six spliced variants have been reported. These share the N-terminal protease domain but differ in the C-terminus, and thus contain varying numbers of CUB and EGF-like domains.

Gene Name: bone morphogenetic protein 1
Family/Subfamily: Protease , Metallopeptidase M12A
Synonyms: BMP1, Bone morphogenetic protein 1, OI13, PCP-2, Procollagen C-proteinase-2, Procollagen C-proteinase, MTld, PCOLC, PCP-1, Procollagen C-endopeptidase, TLD, BMP-1, Mammalian tolloid, Mammalian tolloid protein, PCP
Target Sequences: NM_006129 NP_006120.1 P13497

Publications (1)

1
Cytokine expression in muscle following traumatic injury. Wesley M Jackson, Amber B Aragon, Jun Onodera, Steven M Koehler, Youngmi Ji, Jamie D Bulken-Hoover, Jared A Vogler, Rocky S Tuan, Leon J Nesti. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2011 October;29:1613-20. [Full Text Article] [PubMed:21452302] [PMC:PMC3150639]

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Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
BMP1 (9)
No (9)
GST (1)
GST, N-terminus (1)
His (2)
His-GST (1)
Myc-DDK (Flag) (4)
Human (6)
Mouse (1)
293T Cells (2)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
BMP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
111.21 kDa
20 µg/$215
BMP1 Protein - Recombinant Bone Morphogenetic Protein 1 By SDS-PAGE
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E. coli
His
15.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
BMP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
111.21 kDa
100 µg/$710
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E. coli
His
102.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
BMP1 Protein - 12.5% SDS-PAGE of human BMP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
96.9 kDa
2 µg/$439
BMP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
82.9 kDa
20 µg/$215
BMP1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BMP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
82.9 kDa
100 µg/$710
BMP1 Protein - Recombinant Bone Morphogenetic Protein 1 By SDS-PAGE
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E. coli
His-GST
58.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).