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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
Protein Family And Group
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BMF

Bcl2 modifying factor

Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifying factor). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues.

Gene Name: Bcl2 modifying factor
Family/Subfamily: Apoptosis
Synonyms: BMF, Bcl2 modifying factor, Bcl-2-modifying factor
Target Sequences: NM_033503 NP_277038.1 Q96LC9

Publications (2)

1
BH3 domains other than Bim and Bid can directly activate Bax/Bak. Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T. The Journal of biological chemistry. 2011 286:491-501. (WB; Mouse) [Full Text Article] [PubMed:21041309] [PMC:PMC3013008] Related Antibodies: LS-C4126.
2
2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines. Zagorodna O, Martin SM, Rutkowski DT, Kuwana T, Spitz DR, Knudson CM. Oncogene. 2012 May;31:2738-49. [Full Text Article] [PubMed:21986940] [PMC:PMC3257357] Related Antibodies: LS-C4126.

☰ Filters
Viewing 1-10 of 10 items
BMF Protein - Recombinant Bcl2 Modifying Factor By SDS-PAGE
Select
E. coli
His, N-Terminal
24.0 kDa
10µg   $285.00; 50µg   $465.00; 100µg   $620.00; 200µg   $920.00; 1mg   $2,340.00; 500µg   $1,035.00
BMF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
20.3 kDa
20µg   $195.00
BMF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
20.3 kDa
100µg   $365.00
BMF Protein - 12.5% SDS-PAGE of human BMF stained with Coomassie Blue
Select
Wheat Germ Extract
GST
46.9 kDa
10µg   $425.00; 25µg   $590.00
BMF Protein - Purified recombinant protein BMF was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc + DDK
20.3 kDa
20µg   $890.00
BMF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
GST,N-terminus
1mg   $1,290.00; 500µg   $830.00; 200µg   $485.00; 100µg   $355.00; 50µg   $275.00; 10µg   $245.00
Select
E. coli
His
22.3 kDa
20µg   $415.00; 100µg   $950.00
BMF Protein
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100µg   1mg/ml   $365.00; 0.5mg   1mg/ml   $935.00
Select
E. coli
His
15.6 kDa
5µg   $195.00; 20µg   $255.00; 1mg   $3,780.00
BMF Protein
Select
E. coli
His, N-Terminal
20.3 kDa
50µg   $325.00

Viewing 1-10 of 10 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).