BMF

Bcl2 modifying factor

Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifying factor). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

BMF (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (2)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (1)

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Human BMF Protein (Recombinant His, N-Terminal) (aa1-181) - LS-G14886

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

24.0 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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BMF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122523

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

100 µg/$494

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Human BMF Protein (Recombinant His, N-Terminal) - LS-G144013

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

20.3 kDa

Price:

50 µg/$419

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Human BMF Protein (Recombinant GST) (Full Length) - LS-G35978

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BMF Protein (Recombinant GST, N-terminus) (aa1-184) - LS-G56872

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human BMF Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68958

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

20 µg/$1,107

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Human BMF Protein (Recombinant His) (Met1-Arg184) - LS-G97190

Source:

E. coli

Tag:

His

Molecular Weight:

22.3 kDa

Price:

100 µg/$843

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Human BMF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83501

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

20 µg/$150

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Human BMF Protein (Recombinant) - LS-G546

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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