BLNK

B-cell linker

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

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Products

Proteins (12)

Type

Over-Expression Lysate (4)

Recombinant (8)

Target

BLNK (12)

Publications

No (12)

Tag

6His, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His,C-terminus (1)

His,N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (10)

Source

293T Cells (2)

E. coli (5)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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BLNK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124323

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

100 µg/$494

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Human BLNK Protein (Recombinant GST, N-terminus) (aa301-400) - LS-G62302

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human BLNK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89799

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

20 µg/$150

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Human BLNK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89800

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.3 kDa

Price:

20 µg/$150

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Human BLNK Protein (Recombinant His,C-terminus) (Met1-Ser456) - LS-G140588

Source:

E. coli

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

51.5 kDa

Price:

10 µg/$317; 50 µg/$524

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Human BLNK Protein (Recombinant His,N-terminus) (Met1-Ser456) - LS-G140732

Source:

HEK 293 Cells

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53 kDa

Price:

50 µg/$721

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Human BLNK Protein (Recombinant His, N-Terminal) - LS-G145268

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.2 kDa

Price:

50 µg/$419

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Human BLNK Protein (Recombinant GST) (Full Length) - LS-G33422

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.9 kDa

Price:

10 µg/$479; 25 µg/$670

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BLNK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101128

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.3 kDa

Price:

100 µg/$494

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Human BLNK Protein (Recombinant His) - LS-G1139

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human BLNK Protein (Recombinant 6His, C-terminus) (Met1-Ser456) - LS-G39554

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

51.5kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human BLNK Protein (Recombinant His-T7) (aa65-314) - LS-G14038

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.1 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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