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BLM
Bloom syndrome, RecQ helicase-like
Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).
| Gene Name: | Bloom syndrome, RecQ helicase-like |
| Synonyms: | BLM, Bloom syndrome, Bloom syndrome protein, BS, Bloom's syndrome protein, DNA helicase, RecQ-like type 2, RECQ2, RECQL2, RECQL3, RecQ protein-like 3 |
| Target Sequences: | NM_000057 NP_000048.1 P54132 |
Publications (2)
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