BIRC7 / Livin

baculoviral IAP repeat containing 7

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

BIRC7 / Livin (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (1)

His (2)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (3)

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BIRC7 / Livin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110419

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.7 kDa

Price:

100 µg/$494

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Human BIRC7 / Livin Protein (Recombinant GST) (Full Length) - LS-G35196

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

59.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BIRC7 / Livin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72176

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.6 kDa

Price:

20 µg/$1,107

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Human BIRC7 / Livin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72177

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.7 kDa

Price:

20 µg/$1,107

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Human BIRC7 / Livin Protein (Recombinant GST, N-terminus) (aa1-90) - LS-G63178

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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BIRC7 / Livin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102270

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.6 kDa

Price:

100 µg/$494

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Human BIRC7 / Livin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91612

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.7 kDa

Price:

20 µg/$150

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Human BIRC7 / Livin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91613

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.6 kDa

Price:

20 µg/$150

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Human BIRC7 / Livin Protein (Recombinant His) - LS-G3489

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human BIRC7 / Livin Protein (Recombinant His) - LS-G1639

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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