BIRC7 / Livin

baculoviral IAP repeat containing 7

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

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Products

ELISA Kits (6)

Type

Custom (1)

Sandwich (5)

Target

BIRC7 / Livin (6)

Reactivity

Human (6)

Format

96-Well Microplate (3)

96-Well Strip Plate (3)

Publications

No (6)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (2)

Plasma (4)

Serum (5)

Tissue Homogenates (3)

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Human BIRC7 / Livin (Custom ELISA) ELISA Kit - LS-F358

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$610

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Human BIRC7 / Livin (Sandwich ELISA) ELISA Kit - LS-F36025

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human BIRC7 / Livin (Sandwich ELISA) ELISA Kit - LS-F10508

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Serum, Tissue Homogenates

Price:

1 Plate/$699

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Human BIRC7 / Livin (Sandwich ELISA) ELISA Kit - LS-F24244

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human BIRC7 / Livin (Sandwich ELISA) ELISA Kit - LS-F25513

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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Human BIRC7 / Livin (Sandwich ELISA) ELISA Kit - LS-F31447

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

780 - 50000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

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