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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BIRC3 / cIAP2

baculoviral IAP repeat containing 3

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Gene Name: baculoviral IAP repeat containing 3
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: BIRC3, AIP1, API2, Apoptosis inhibitor 2, CIAP2, Hiap-1, HIAP1, IAP homolog C, Mammalian IAP homolog C, MIHC, IAP-1, IAP1, RING finger protein 49, RNF49, C-IAP2, HAIP1, MALT2
Target Sequences: NM_001165 NP_001156.1 Q13489

Publications (3)

1
Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. Wldele K, Silbermann K, Schneider G, Ruckes T, Cullen BR, Grassmann R. Blood. 2006 107:4491-9. (WB) [PubMed:16467195]
2
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Guicciardi ME, Mott JL, Bronk SF, Kurita S, Fingas CD, Gores GJ. Experimental cell research. 2011 317:107-16. [PubMed:20951133] [PMC:PMC2991414]
3
Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. Kurita S, Mott JL, Cazanave SC, Fingas CD, Guicciardi ME, Bronk SF, Roberts LR, Fernandez-Zapico ME, Gores GJ. PloS one. 2011 6:e18330. [PubMed:21483830] [PMC:PMC3069071]

Filtered by: None
Target
BIRC3 / cIAP2 (68)
Reactivity
Human (68)
Mouse (3)
Rat (2)
Monkey (2)
Application
IHC (29)
IHC-Fr (2)
IHC-P (13)
WB (53)
Flo (4)
ELISA (27)
ICC (9)
IF (15)
IP (2)
Peptide-ELISA (2)
Host
rabbit (47)
mouse (19)
goat (2)
Isotype
IgG (36)
IgG1 (17)
Clonality
monoclonal mc (19)
polyclonal pc (49)
Clone
1D4B (1)
OTI1A9 (2)
OTI1D12 (2)
OTI1E3 (2)
OTI1F5 (2)
OTI2B2 (2)
OTI2B7 (2)
OTI2G7 (2)
OTI3G4 (2)
Format
AP Conjugated (3)
APC Conjugated (3)
Biotin Conjugated (8)
Carrier-free (8)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Preservative Free (6)
Unconjugated (40)
Epitope
aa255-529 (13)
N-Terminus (8)
aa59-88 (8)
aa100-200 (4)
Internal (1)
aa1-191 (1)
aa101-111 (1)
aa109-118 (1)
aa152-172 (1)
aa2-604 (1)
aa532-549 (1)
Publications
No (68)
Showing 1-25 of 68 results

IHC-plus™ BIRC3 / cIAP2 Antibody (aa101-111) LS-B11176
Goat Polyclonal to Human BIRC3 / cIAP2
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-BIRC3 / cIAP2 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
BIRC3 antibody (1 ug/ml) staining of Rat Testis lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

IHC-plus™ BIRC3 / cIAP2 Antibody LS-B4869
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
IHC, IHC-P, WB
Unconjugated
50µl 0.67mg/ml  $425.00
Anti-cIAP2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-cIAP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

IHC-plus™ BIRC3 / cIAP2 Antibody LS-B5024
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µg 0.2mg/ml  $425.00
Anti-cIAP2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western blot of BIRC3 / cIAP2 antibody.

BIRC3 / cIAP2 Antibody (Preservative Free) LS-C149194
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA
Unconjugated, Preservative Free
20µg  $195.00; 100µg  $265.00; 200µg  $295.00; 500µg  $415.00

BIRC3 / cIAP2 Antibody LS-C500898
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
50µg 2mg/ml  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human tonsil tissue using BIRC3 Antibody at dilution of 1:100
Positive WB detected in:Mouse lung tissue;All lanes: BIRC3 antibody at 4ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 69 kDa;Observed band size: 69 kDa;

BIRC3 / cIAP2 Antibody (aa2-604, clone 1D4B) LS-C189776
Mouse Monoclonal [clone 1D4B] (IgG1) to Human BIRC3 / cIAP2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100µg  $680.00

BIRC3 / cIAP2 Antibody (Preservative Free) LS-C343317
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, WB
Unconjugated, Preservative Free
20µg  $195.00; 100µg  $265.00; 200µg  $295.00; 500µg  $415.00
Immunodetection Analysis: Representative blot from a previous lot. Lane 1, recombinant protein TnI. The membrane blot was probed with anti-TnI primary antibody (1µg/ml). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to IRDye 800CW detection system. Arrows indicate cellular TNi from human and mouse cells (27 kDa).

BIRC3 / cIAP2 Antibody (Preservative Free, Biotin) LS-C342905
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50µg  $295.00
Immunodetection Analysis: Representative blot from a previous lot. Lane 1, recombinant protein TnI. The membrane blot was probed with anti-TnI primary antibody (1µg/ml). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to IRDye 800CW detection system. Arrows indicate cellular TNi from human and mouse cells (27 kDa).

IHC-plus™ BIRC3 / cIAP2 Antibody (aa109-118) LS-B11177
Goat Polyclonal to Human BIRC3 / cIAP2
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg  $425.00
Anti-BIRC3 / cIAP2 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
BIRC3 antibody (0.1 ug/ml) staining of HeLa lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

BIRC3 / cIAP2 Antibody (Preservative Free) LS-C343318
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA
Unconjugated, Preservative Free
20µg  $195.00; 100µg  $265.00; 200µg  $295.00; 500µg  $415.00

BIRC3 / cIAP2 Antibody (aa59-88) LS-C156821
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
BIRC3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human tonsil tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Confocal immunofluorescence of BIRC3 Antibody with MDA-MB435 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).

BIRC3 / cIAP2 Antibody (Internal) LS-C142732
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl  $335.00
cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
cIAP2/HIAD1 Antibody - Western blot on HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BIRC3 / cIAP2 Antibody (aa100-200, Biotin) LS-C143142
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
100µl  $365.00
cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
cIAP2/HIAD1 Antibody - Western blot on HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BIRC3 / cIAP2 Antibody (aa100-200, DY650) LS-C143143
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
100µl  $365.00
cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
cIAP2/HIAD1 Antibody - Western blot on HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BIRC3 / cIAP2 Antibody (aa100-200, DY488) LS-C143144
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
100µl  $365.00
cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
cIAP2/HIAD1 Antibody - Western blot on HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BIRC3 / cIAP2 Antibody (aa100-200, DY550) LS-C143146
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
100µl  $365.00
cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
cIAP2/HIAD1 Antibody - Western blot on HeLa whole cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BIRC3 / cIAP2 Antibody (aa59-88) LS-C319845
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, IF, IHC, WB
Unconjugated
200µl  $590.00

BIRC3 / cIAP2 Antibody (aa59-88, Biotin) LS-C520152
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, IF, IHC, WB
Biotin Conjugated
200µl  $740.00

BIRC3 / cIAP2 Antibody (aa59-88, FITC) LS-C252586
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200µl  $740.00

BIRC3 / cIAP2 Antibody (aa59-88, AP) LS-C252584
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200µl  $740.00

BIRC3 / cIAP2 Antibody (aa59-88, APC) LS-C252585
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200µl  $740.00

BIRC3 / cIAP2 Antibody (aa59-88, PE) LS-C252588
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200µl  $740.00

BIRC3 / cIAP2 Antibody LS-C664606
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, IF, IHC, WB
Unconjugated
100µg  $335.00

BIRC3 / cIAP2 Antibody (aa532-549) LS-C148260
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human, Monkey
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl  $335.00
IHC of cIAP2 in paraffin-embedded formalin-fixed human mammary gland (female breast) using Polyclonal Antibody to cIAP2 at 1:2000. A, normal breast tissue. B, ductal carcinoma in situ (DCIS). C. invasive neoplasia. cIAP2 expressed increased successively with tumor progression. Hematoxylin-Eosin counterstain.
Western blot of cIAP2 in various cancer cell lines using Polyclonal Antibody to cIAP2 at 1:2000.

BIRC3 / cIAP2 Antibody (aa152-172) LS-C148261
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl  $335.00
IHC of cIAP2 in paraffin-embedded formalin-fixed tissue using Polyclonal Antibody to cIAP2 at 1:2000. A. Human brain tumor microarray showing differential expression of cIAP2. B-E, Higher magnification of selected high grade brain tumor tissue cores from A. Tumor types: PNET (B), ependymoblastoma (C), anaplastic oliogdendroglioma (D), glioblastoma multiforme (E). Strong staining in high grade brain tumors implies malignancy-associated deregulated cIAP2 expression. Hematoxylin-Eosin counterstain.
IHC of cIAP2 in paraffin-embedded formalin-fixed normal human brain tissue cores from a microarray using Polyclonal Antibody to cIAP2 at 1:2000. A. Tissue cores. A1 and A2, successively higher magnifications of a tissue core from A. Hematoxylin-Eos in counterstain.
Showing 1-25 of 68 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).