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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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BIRC3 / cIAP2

baculoviral IAP repeat containing 3

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Gene Name: baculoviral IAP repeat containing 3
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: BIRC3, AIP1, API2, Apoptosis inhibitor 2, CIAP2, Hiap-1, HIAP1, IAP homolog C, Mammalian IAP homolog C, MIHC, IAP-1, IAP1, RING finger protein 49, RNF49, C-IAP2, HAIP1, MALT2
Target Sequences: NM_001165 NP_001156.1 Q13489

Publications (3)

1
Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. Wldele K, Silbermann K, Schneider G, Ruckes T, Cullen BR, Grassmann R. Blood. 2006 107:4491-9. (WB) [PubMed:16467195]
2
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Guicciardi ME, Mott JL, Bronk SF, Kurita S, Fingas CD, Gores GJ. Experimental cell research. 2011 317:107-16. [PubMed:20951133] [PMC:PMC2991414]
3
Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. Kurita S, Mott JL, Cazanave SC, Fingas CD, Guicciardi ME, Bronk SF, Roberts LR, Fernandez-Zapico ME, Gores GJ. PloS one. 2011 6:e18330. [PubMed:21483830] [PMC:PMC3069071]

Viewing 1-25 of 69 items
BIRC3 / cIAP2 Antibody - Anti-BIRC3 / cIAP2 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Human BIRC3 / cIAP2
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
BIRC3 / cIAP2 Antibody - Anti-cIAP2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
IHC, IHC-P, WB
Unconjugated
50µl   0.67mg/ml   $425.00
BIRC3 / cIAP2 Antibody - Anti-cIAP2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µg   0.2mg/ml   $425.00
BIRC3 / cIAP2 Antibody - Anti-BIRC3 / cIAP2 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Human BIRC3 / cIAP2
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   $425.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA
Unconjugated, Preservative Free
20µg   $195.00; 100µg   $265.00; 200µg   $295.00; 500µg   $415.00
BIRC3 / cIAP2 Antibody - Immunohistochemistry of paraffin-embedded human tonsil tissue using BIRC3 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
50µg   2mg/ml   $285.00; 100µg   $385.00
Select
Mouse Monoclonal [clone 1D4B] (IgG1) to Human BIRC3 / cIAP2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100µg   $680.00
BIRC3 / cIAP2 Antibody - Immunodetection Analysis: Representative blot from a previous lot. Lane 1, recombinant protein TnI. The membrane blot was probed with anti-TnI primary antibody (1µg/ml). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to IRDye 800CW detection system. Arrows indicate cellular TNi from human and mouse cells (27 kDa).
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, WB
Unconjugated, Preservative Free
20µg   $195.00; 100µg   $265.00; 200µg   $295.00; 500µg   $415.00
BIRC3 / cIAP2 Antibody - Immunodetection Analysis: Representative blot from a previous lot. Lane 1, recombinant protein TnI. The membrane blot was probed with anti-TnI primary antibody (1µg/ml). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to IRDye 800CW detection system. Arrows indicate cellular TNi from human and mouse cells (27 kDa).
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50µg   $295.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA
Unconjugated, Preservative Free
20µg   $195.00; 100µg   $265.00; 200µg   $295.00; 500µg   $415.00
BIRC3 / cIAP2 Antibody - BIRC3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human tonsil tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, IF, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, IF, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200µl   $740.00
BIRC3 / cIAP2 Antibody - cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   $335.00
BIRC3 / cIAP2 Antibody - cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
100µl   $365.00
BIRC3 / cIAP2 Antibody - cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
100µl   $365.00
BIRC3 / cIAP2 Antibody - cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
100µl   $365.00
BIRC3 / cIAP2 Antibody - cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
100µl   $365.00
Select
Rabbit Polyclonal (IgG) to Human BIRC3 / cIAP2
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $355.00
BIRC3 / cIAP2 Antibody - IHC of cIAP2 in paraffin-embedded formalin-fixed tissue using Polyclonal Antibody to cIAP2 at 1:2000. A. Human brain tumor microarray showing differential expression of cIAP2. B-E, Higher magnification of selected high grade brain tumor tissue cores from A. Tumor types: PNET (B), ependymoblastoma (C), anaplastic oliogdendroglioma (D), glioblastoma multiforme (E). Strong staining in high grade brain tumors implies malignancy-associated deregulated cIAP2 expression. Hematoxylin-Eosin counterstain.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
BIRC3 / cIAP2 Antibody - IHC of cIAP2 in paraffin-embedded formalin-fixed human mammary gland (female breast) using Polyclonal Antibody to cIAP2 at 1:2000. A, normal breast tissue. B, ductal carcinoma in situ (DCIS). C. invasive neoplasia. cIAP2 expressed increased successively with tumor progression. Hematoxylin-Eosin counterstain.
Select
Rabbit Polyclonal to Human BIRC3 / cIAP2
Human, Monkey
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00

Viewing 1-25 of 69 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).