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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BIRC2 / cIAP1

baculoviral IAP repeat containing 2

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Gene Name: baculoviral IAP repeat containing 2
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: BIRC2, API1, C-IAP1, CIAP1, Hiap-2, IAP homolog B, HIAP2, IAP-2, RNF48, Apoptosis inhibitor 1, IAP2, MIHB, RING finger protein 48
Target Sequences: NM_001166 NP_001157.1 Q13490

Filtered by: None
Target
BIRC2 / cIAP1 (59)
Reactivity
Human (59)
Mouse (13)
Rat (10)
Dog (2)
Gerbil (2)
Monkey (1)
Application
IHC (31)
IHC-Fr (3)
IHC-P (10)
WB (56)
ELISA (17)
IF (4)
IP (6)
Host
rabbit (58)
mouse (1)
Isotype
IgG (29)
Clonality
monoclonal mc (1)
polyclonal pc (58)
Format
AP Conjugated (2)
APC (2)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (4)
Unconjugated (30)
Epitope
aa148-298 (8)
aa216-244 (8)
aa344-593 (8)
Internal (1)
aa1-300 (1)
aa158-175 (1)
aa2-18 (1)
aa361-72 (1)
Publications
No (59)
Showing 1-25 of 59 results

BIRC2 / cIAP1 Antibody IHC-plus™ LS-B179
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Mouse, Human
ELISA IF IHC IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-cIAP1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of cIAP in Human Lung cells with cIAP antibody at 20 ug/ml.

BIRC2 / cIAP1 Antibody IHC-plus™ LS-B8247
Rabbit Polyclonal to Human BIRC2 / cIAP1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µg 100µl 0.5mg/ml  $425.00
Anti-BIRC2 / cIAP1 antibody IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Western blot of BIRC2 / cIAP1 antibody with mouse small intestine lysates.

BIRC2 / cIAP1 Antibody LS-C148258
Rabbit Polyclonal to Human BIRC2 / cIAP1
Mouse, Dog, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
IHC of cIAP1 in formalin-fixed, paraffin-embedded human prostate using Polyclonal Antibody to cIAP1 at 1:2000. A, normal prostate. B, prostate intraepithelial neoplasia (PIN). PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-Eosin counterstain. Increased cIAP1 expression is PIN and in prostate cancer compared to normal prostate.
Western blot of cIAP1 in human prostate using Polyclonal Antibody to cIAP1 at 1:1000. PBH (benign prostate hyperplasia), PIN (prostate intraepithelial neoplasia). Elevated levels of cIAP1 were seen in certain cases of BPH/PIN and prostate cancer compared to normal prostate.

BIRC2 / cIAP1 Antibody IHC-plus™ LS-B2017
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-cIAP1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:250.
Anti-cIAP1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:250.

BIRC2 / cIAP1 Antibody (aa148-298, Biotin) LS-C301189
Rabbit Polyclonal to Human BIRC2 / cIAP1
Human
WB
Biotin Conjugated
200µl 0.5mg/ml  $315.00; 100µl 0.25mg/ml  $425.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,310.00
Western blot of recombinant BIRC2 / cIAP1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot; Sample: Recombinant protein.

BIRC2 / cIAP1 Antibody (aa2-18) LS-C148259
Rabbit Polyclonal to Human BIRC2 / cIAP1
Human, Monkey
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
IHC of a formalin-fixed, paraffin-embedded human ovarian cancer tissue microarray using Polyclonal Antibody to cIAP1 at 1:2000. Differential expression of cIAP1 is seen between patient samples. Hematoxylin-Eosin counterstain.
IHC of formalin-fixed, paraffin-embedded human breast tissue using Polyclonal Antibody to cIAP1 at 1:2000. A, normal breast tissue. B, ductal carcinoma in situ (DCIS). C, invasive breast carcinoma. A1, B1, and C1 are higher magnifications of A, B and C, respectively. Hematoxylin-Eos in counterstain. IncreasedcIAP1 expression is seen in the cancerous compared to normal breast tissue. Hematoxylin-Eos in counterstain.

BIRC2 / cIAP1 Antibody (aa158-175) LS-C148257
Rabbit Polyclonal to Human BIRC2 / cIAP1
Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
Immun histochemical analysis of cIAP1 expression in formalin-fixed, paraffin-embedded human gliomas from a brain tissue microarray using Polyclonal Antibody to cIAP1 at 1:2000. A. Two tissue cores showing a gemistocytoma, grade II tumor (left) and an anaplastic glioma-glioblastoma, grade IV tumor (right). A1 and A2, higher magnifications of the gemistocytoma. A3, higher magnification of the anaplastic glioma-glioblastoma. Hematoxylin-Eosin counterstain. Higher cIAP1 expression is seen in the less malignant tumor (gemistocytoma) than the more malignant anaplastic (glioma-glioblastoma) tumor.
Western blot of cIAP1 in various cancer cell lines using Polyclonal Antibody to cIAP1 at 1:2000.

BIRC2 / cIAP1 Antibody (aa216-244) LS-C319844
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IHC WB
Unconjugated
200µl  $590.00

BIRC2 / cIAP1 Antibody (aa216-244, Biotin) LS-C252580
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IHC WB
Biotin Conjugated
200µl  $740.00

BIRC2 / cIAP1 Antibody (aa216-244, FITC) LS-C252579
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IHC WB
FITC Conjugated
200µl  $740.00

BIRC2 / cIAP1 Antibody (aa216-244, AP) LS-C252576
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IHC WB
AP Conjugated
200µl  $740.00

BIRC2 / cIAP1 Antibody (aa216-244, APC) LS-C252578
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IHC WB
APC Conjugated
200µl  $740.00

BIRC2 / cIAP1 Antibody (aa216-244, PE) LS-C252581
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IHC WB
PE Conjugated
200µl  $740.00

BIRC2 / cIAP1 Antibody (aa216-244, Azide-free, HRP) LS-C252582
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $740.00

BIRC2 / cIAP1 Antibody LS-C664604
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IF IHC WB
Unconjugated
100µg  $355.00

BIRC2 / cIAP1 Antibody (aa216-244) IHC-plus™ LS-B13208
Rabbit Polyclonal to Human BIRC2 / cIAP1
Human
IHC IHC-P WB
Unconjugated
200µl  $425.00
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
BIRC2 Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The BIRC2 antibody detected the BIRC2 protein (arrow).

BIRC2 / cIAP1 Antibody IHC-plus™ LS-B8729
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µg 250µl 0.2mg/ml  $485.00
Anti-BIRC2 / cIAP1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Western blot of BIRC2 / cIAP1 antibody.

BIRC2 / cIAP1 Antibody (aa1-300) LS-C377442
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human testis using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human liver using antibody at 1:100 dilution.

BIRC2 / cIAP1 Antibody LS-C331184
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded rat heart.
Immunofluorescence analysis of A549 cells.

BIRC2 / cIAP1 Antibody LS-C404324
Rabbit Polyclonal (IgG) to Human BIRC2 / cIAP1
Mouse, Human
ELISA IHC WB
Unconjugated
20µl 0.1mg/ml  $205.00; 60µl 0.1mg/ml  $235.00; 120µl 0.1mg/ml  $295.00; 200µl 0.1mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human liver cancer using BIRC2 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of paraffin-embedded Human lung cancer using BIRC2 Polyclonal Antibody at dilution of 1:20.

BIRC2 / cIAP1 Antibody LS-C358735
Rabbit Polyclonal to Human BIRC2 / cIAP1
Mouse, Dog, Rat, Gerbil, Human
IHC IP WB
Unconjugated
50µl  $325.00

BIRC2 / cIAP1 Antibody LS-C358687
Rabbit Polyclonal to Human BIRC2 / cIAP1
Human
IHC IP WB
Unconjugated
50µl  $325.00

BIRC2 / cIAP1 Antibody LS-C358688
Rabbit Polyclonal to Human BIRC2 / cIAP1
Human
IHC IP WB
Unconjugated
50µl  $325.00

BIRC2 / cIAP1 Antibody (aa344-593) LS-C374803
Rabbit Polyclonal to Human BIRC2 / cIAP1
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

BIRC2 / cIAP1 Antibody LS-C192309
Rabbit Polyclonal to Human BIRC2 / cIAP1
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $385.00
Western blot of BIRC2 pAb in extracts from Jurkat, Hela and HT29 cells.
Showing 1-25 of 59 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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