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BCL2L2 / Bcl-w

BCL2-like 2

BCL2L2 / Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.

Gene Name: BCL2-like 2
Family/Subfamily: Apoptosis
Synonyms: BCL2L2, BCLW, BCL2-L-2, KIAA0271, PPP1R51, Apoptosis regulator Bcl-W, Bcl-2-like protein 2, BCL-W, BCL2-like 2
Target Sequences: NM_004050 NP_004041.1 Q92843

Publications (2)

1
Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Ernesto Diaz-Flores, Evan Q Comeaux, Kailyn L Kim, Ella Melnik, Kyle Beckman, Kara L Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S Braun, Charles G Mullighan, Mignon L Loh. Cancer research. 2019 May;79:2339-2351. [Full Text Article] [PubMed:30862722] [PMC:PMC6497548] Related Antibodies: LS-C382259.
2
CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation. Rubina Tuladhar, Yunku Yeu, John Tyler Piazza, Zhen Tan, Jean Rene Clemenceau, Xiaofeng Wu, Quinn Barrett, Jeremiah Herbert, David H Mathews, James Kim, Tae Hyun Hwang, Lawrence Lum. Nature communications. 2019 September;10:4056. [Full Text Article] [PubMed:31492834] [PMC:PMC6731291] Related Antibodies: LS-C382259.

☰ Filters
Products
Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
BCL2L2 / Bcl-w (11)
No (11)
6His, C-terminus (2)
GST (1)
His (4)
His-SUMO (1)
Myc-DDK (Flag) (3)
Dog (1)
Human (8)
Mouse (1)
293T Cells (1)
E. coli (7)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
BCL2L2 / Bcl-w Protein
Select
E. coli
His-SUMO
36.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
BCL2L2 / Bcl-w Protein - 12.5% SDS-PAGE of human BCL2L2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
46.86 kDa
10 µg/$479; 25 µg/$670
BCL2L2 / Bcl-w Protein - Purified recombinant protein BCL2L2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
20.6 kDa
20 µg/$1,107
BCL2L2 / Bcl-w Protein
Select
E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
19.87kD
10 µg/$269; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
19.9 kDa
10 µg/$358; 50 µg/$479
BCL2L2 / Bcl-w Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.6 kDa
100 µg/$494
BCL2L2 / Bcl-w Protein - Recombinant B-Cell CLL/Lymphoma 2 Like Protein 2 By SDS-PAGE
Select
E. coli
His
47.7 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
BCL2L2 / Bcl-w Protein - Recombinant B-Cell CLL/Lymphoma 2 Like Protein 2 By SDS-PAGE
Select
E. coli
His
19.3 kDa
10 µg/$288; 50 µg/$485; 100 µg/$775; 200 µg/$970; 1 mg/$2,104; 500 µg/$1,632; 5 mg/$3,389; 2 mg/$2,294
BCL2L2 / Bcl-w Protein - Recombinant B-Cell CLL/Lymphoma 2 Like Protein 2 By SDS-PAGE
Select
E. coli
His
19.7 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
BCL2L2 / Bcl-w Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
20.6 kDa
20 µg/$150
Viewing 1-11 of 11 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).