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BCL2L14 / BCL-G

BCL2-like 14 (apoptosis facilitator)

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G. The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein.

Gene Name: BCL2-like 14 (apoptosis facilitator)
Family/Subfamily: Apoptosis
Synonyms: BCL2L14, Bcl2-L-14, BCLG, BCL-G, Apoptosis regulator Bcl-G
Target Sequences: NM_030766 NP_110393.1 Q9BZR8

Publications (1)

1
A novel role for proline- and acid-rich basic region leucine zipper (PAR bZIP) proteins in the transcriptional regulation of a BH3-only proapoptotic gene. Benito A, Gutierrez O, Pipaon C, Real PJ, Gachon F, Ritchie AE, Fernandez-Luna JL. The Journal of biological chemistry. 2006 281:38351-7. [PubMed:17057225]

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Proteins (13)
Over-Expression Lysate (9)
Recombinant (4)
BCL2L14 / BCL-G (13)
No (13)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (11)
Human (9)
293T Cells (5)
E. coli (1)
HEK 293 Cells (6)
Wheat Germ Extract (1)
Purified (2)
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293T Cells
Myc-DDK (Flag)
27.9 kDa
20 µg/$150
BCL2L14 / BCL-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
36.4 kDa
20 µg/$150
BCL2L14 / BCL-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.4 kDa
20 µg/$150
BCL2L14 / BCL-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
30.8 kDa
20 µg/$150
BCL2L14 / BCL-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.9 kDa
20 µg/$150
BCL2L14 / BCL-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
36.4 kDa
100 µg/$494
BCL2L14 / BCL-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
36.4 kDa
100 µg/$494
BCL2L14 / BCL-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
30.8 kDa
100 µg/$494
BCL2L14 / BCL-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.9 kDa
100 µg/$494
BCL2L14 / BCL-G Protein - 12.5% SDS-PAGE of human BCL2L14 stained with Coomassie Blue
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Wheat Germ Extract
GST
61.71 kDa
10 µg/$479; 25 µg/$670
BCL2L14 / BCL-G Protein - Purified recombinant protein BCL2L14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
36.4 kDa
20 µg/$1,107
BCL2L14 / BCL-G Protein - Purified recombinant protein BCL2L14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
36.4 kDa
20 µg/$1,107
BCL2L14 / BCL-G Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Viewing 1-13 of 13 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).