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BCL2A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | BCL2-related protein A1 |
Family/Subfamily: | Apoptosis |
Synonyms: | BCL2A1, ACC-1, ACC-2, Bcl-2-like protein 5, Bcl-2-related protein A1, BCL2-related protein A1, BFL1, Bcl2-L-5, BCL2L5, GRS, HBPA1, Protein BFL-1, Protein GRS |
Target Sequences: | NM_004049 NP_004040.1 Q16548 |
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