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BCL2 / Bcl-2

B-cell CLL/lymphoma 2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Gene Name: B-cell CLL/lymphoma 2
Family/Subfamily: Apoptosis
Synonyms: BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50
Target Sequences: NM_000633 NP_000624.2 P10415

Publications (8)

1
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Cancer cell. 2007 12:171-85. (IP) [PubMed:17692808]
2
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. The Journal of biological chemistry. 2012 287:1054-65. [PubMed:22065578] [PMC:PMC3256916] Related Antibodies: LS-C98842.
3
The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Hamed SS, Al-Yhya NA, El-Khadragy MF, Al-Olayan EM, Alajmi RA, Hassan ZK, Hassan SB, Abdel Moneim AE. Frontiers in physiology. 2016 August;7:325. [Full Text Article] [PubMed:27547187] [PMC:PMC4974471]
4
Bmi-1 in gallbladder carcinoma: Clinicopathology and mechanism of regulation of human gallbladder carcinoma proliferation. Jiao K, Jiang W, Zhao C, Su D, Zhang H. Oncology letters. 2019 August;18:1365-1371. [Full Text Article] [PubMed:31423199] [PMC:PMC6607302] Related Antibodies: LS-B6548.
5
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses. Matteo Ugolini, Jenny Gerhard, Sanne Burkert, Kristoffer Jarlov Jensen, Philipp Georg, Friederike Ebner, Sarah M Volkers, Shruthi Thada, Kristina Dietert, Laura Bauer, Alexander Schäfer, Elisa T Helbig, Bastian Opitz, Florian Kurth, Saubashya Sur, Nickel Dittrich, Sumanlatha Gaddam, Melanie L Conrad, Christine S Benn, Ulrike Blohm, Achim D Gruber, Andreas Hutloff, Susanne Hartmann, Mark V Boekschoten, Michael Müller, Gregers Jungersen, Ralf R Schumann, Norbert Suttorp, Leif E Sander. Nature immunology. 2018 April;19:386-396. [Full Text Article] [PubMed:29556002]
6
The Beneficial Effect of Eco-Friendly Green Nanoparticles Using Garcinia mangostana Peel Extract against Pathogenicity of Listeria monocytogenes in Female BALB/c Mice. Afrah F Alkhuriji, Nada A Majrashi, Suliman Alomar, Manal F El-Khadragy, Manal A Awad, Alaa R Khatab, Hany M Yehia. Animals: an open access journal from MDPI. 2020 Mar;10:573. [Full Text Article] [PubMed:32235366] [PMC:PMC7222409]
7
Translational control of Bcl-2 promotes apoptosis of gastric carcinoma cells. Shuangfen Tao, Jianchun Gu, Qing Wang, Leizhen Zheng. BMC cancer. 2021 Jan;21:12. [Full Text Article] [PubMed:33402109] [PMC:PMC7786514]
8
LncRNA H19 aggravates TNF-a-induced inflammatory injury via TAK1 pathway in MH7A cells. Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia. BioFactors (Oxford, England). 2020 September;46:813-820. [Full Text Article] [PubMed:32525617] Related Antibodies: LS-C343557.
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Proteins (17)
Over-Expression Lysate (5)
Recombinant (12)
BCL2 / Bcl-2 (17)
No (17)
6His, C-terminus (1)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (3)
His, N-Terminal (1)
His,C-terminus (1)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (12)
Mouse (2)
Rat (1)
293T Cells (2)
E. coli (9)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (2)
BCL2 / Bcl-2 Protein
Select
Human BCL2 / Bcl-2 Protein (Recombinant His) - LS-G532
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
BCL2 / Bcl-2 Protein
Select
Mouse BCL2 / Bcl-2 Protein (Recombinant His) (aa5-205) - LS-G20520
E. coli
His
26.8 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
BCL2 / Bcl-2 Protein - Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) by SDS-PAGE
Select
Rat BCL2 / Bcl-2 Protein (Recombinant His, N-Terminal) (Ala2-Asp208) - LS-G133059
E. coli
His, N-Terminal
27.4kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
BCL2 / Bcl-2 Protein - Recombinant B-Cell Leukemia/Lymphoma 2 By SDS-PAGE
Select
Mouse BCL2 / Bcl-2 Protein (Recombinant His-GST) (aa2-208) - LS-G12800
E. coli
His-GST
27.2 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
BCL2 / Bcl-2 Protein - 12.5% SDS-PAGE of human BCL2 stained with Coomassie Blue
Select
Human BCL2 / Bcl-2 Protein (Recombinant GST) (Full Length) - LS-G27609
Wheat Germ Extract
GST
52.7 kDa
10 µg/$479; 25 µg/$670
Select
Human BCL2 / Bcl-2 Protein (Over-Expression Lysate 6His, N-terminus) (Ala2-Lys240) - LS-G26665
HEK 293 Cells
6His, N-terminus
27 kDa
100 µg/$298
BCL2 / Bcl-2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Human BCL2 / Bcl-2 Protein (Recombinant GST, N-terminus) (aa140-239) - LS-G57881
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BCL2 / Bcl-2 Protein - Purified recombinant protein BCL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
Human BCL2 / Bcl-2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64968
HEK 293 Cells
Myc-DDK (Flag)
26.1 kDa
20 µg/$1,107
Select
Human BCL2 / Bcl-2 Protein (Recombinant 6His, C-terminus) (Met1-Asp211) - LS-G51879
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.1kD
10 µg/$281; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627
BCL2 / Bcl-2 Protein
Select
Human BCL2 / Bcl-2 Protein (Recombinant 6His, N-terminus) (Ala2-Lys240) - LS-G26469
E. coli
6His, N-terminus
26.64 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
Select
Human BCL2 / Bcl-2 Protein (Recombinant His,C-terminus) (Met1-Asp211) - LS-G139424
E. coli
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.1 kDa
10 µg/$368; 50 µg/$479
Select
Human BCL2 / Bcl-2 Protein (Recombinant His) (Met1-Asp211) - LS-G97179
E. coli
His
24.7 kDa
100 µg/$721
BCL2 / Bcl-2 Protein - Recombinant B-Cell Leukemia/Lymphoma 2 By SDS-PAGE
Select
Human BCL2 / Bcl-2 Protein (Recombinant His-T7) (aa2-211) - LS-G12806
E. coli
His-T7
27 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
BCL2 / Bcl-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
BCL2 / Bcl-2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123073
HEK 293 Cells
Myc-DDK (Flag)
26.1 kDa
100 µg/$494
BCL2 / Bcl-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human BCL2 / Bcl-2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74557
293T Cells
Myc-DDK (Flag)
26.1 kDa
20 µg/$150
BCL2 / Bcl-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human BCL2 / Bcl-2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74558
293T Cells
Myc-DDK (Flag)
22.2 kDa
20 µg/$150
BCL2 / Bcl-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
BCL2 / Bcl-2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123055
HEK 293 Cells
Myc-DDK (Flag)
22.2 kDa
100 µg/$494
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