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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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BCL2 / Bcl-2

B-cell CLL/lymphoma 2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Gene Name: B-cell CLL/lymphoma 2
Family/Subfamily: Apoptosis
Synonyms: BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50
Target Sequences: NM_000633 NP_000624.2 P10415

Publications (3)

1
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Cancer cell. 2007 12:171-85. (IP) [PubMed:17692808]
2
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. The Journal of biological chemistry. 2012 287:1054-65. [PubMed:22065578] [PMC:PMC3256916] Related Antibodies: LS-C98842.
3
The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Hamed SS, Al-Yhya NA, El-Khadragy MF, Al-Olayan EM, Alajmi RA, Hassan ZK, Hassan SB, Abdel Moneim AE. Frontiers in physiology. 2016 August;7:325. [Full Text Article] [PubMed:27547187] [PMC:PMC4974471]

Viewing 1-25 of 25 items
BCL2 / Bcl-2 Protein
Select
E. coli
His
100µg   0.25mg/ml   $365.00; 0.5mg   0.25mg/ml   $935.00
BCL2 / Bcl-2 Protein
Select
E. coli
His
26.8 kD
1mg   $1,845.00; 500µg   $1,185.00; 200µg   $710.00; 50µg   1.5mg/ml   $325.00; 10µg   $275.00; 100µg   $445.00
BCL2 / Bcl-2 Protein - Recombinant B-Cell Leukemia/Lymphoma 2 By SDS-PAGE
Select
E. coli
His + GST
27.2 kDa
10µg   $255.00; 50µg   $405.00; 100µg   $495.00; 200µg   $740.00; 1mg   $1,890.00; 500µg   $845.00
Select
HEK 293 Cells
6His,N-terminus
27 kDa
100µg   $245.00
BCL2 / Bcl-2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST,N-terminus
10µg   $425.00; 25µg   $590.00
BCL2 / Bcl-2 Protein - Purified recombinant protein BCL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc + DDK
26.1 kDa
20µg   $890.00
BCL2 / Bcl-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
26.1 kDa
20µg   $195.00
BCL2 / Bcl-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
22.2 kDa
20µg   $195.00
Select
E. coli
6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.1kD
10µg   $225.00; 50µg   $335.00; 500µg   $1,170.00; 1mg   $1,680.00
BCL2 / Bcl-2 Protein - Recombinant B-Cell Leukemia/Lymphoma 2 By SDS-PAGE
Select
E. coli
His + T7
27 kDa
10µg   $245.00; 50µg   $375.00; 100µg   $445.00; 200µg   $635.00; 1mg   $1,620.00; 500µg   $725.00
BCL2 / Bcl-2 Protein - 12.5% SDS-PAGE of human BCL2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
52.7 kDa
10µg   $425.00; 25µg   $590.00
Select
E. coli
His
2µg   $195.00; 10µg   $255.00; 1mg   $5,040.00
Select
E. coli
None
23.2 kDa
5µg   $195.00; 20µg   $255.00; 1mg   $2,850.00
Select
E. coli
His
2µg   $195.00; 10µg   $255.00; 1mg   $5,040.00
Select
E. coli
His
2µg   $195.00; 10µg   $255.00; 1mg   $5,040.00
Select
E. coli
His
2µg   $195.00; 10µg   $255.00; 1mg   $5,040.00
Select
E. coli
His
2µg   $195.00; 10µg   $255.00; 1mg   $5,040.00
Select
E. coli
His
2µg   $195.00; 10µg   $255.00; 1mg   $5,040.00
BCL2 / Bcl-2 Protein
Select
E. coli
6His,N-terminus
26.64 kDa
10µg   $215.00; 50µg   $275.00; 100µg   $325.00; 500µg   $875.00
Select
E. coli
His
25.4 kDa
5µg   $195.00; 20µg   $255.00; 1mg   $3,780.00
Select
E. coli
His
24.7 kDa
50µg   $485.00; 100µg   $815.00
BCL2 / Bcl-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
22.2 kDa
100µg   $365.00
BCL2 / Bcl-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
26.1 kDa
100µg   $365.00
Select
E. coli
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.1 kDa
10µg   $295.00; 50µg   $395.00
BCL2 / Bcl-2 Protein - Recombinant B-Cell Leukemia/Lymphoma 2 (Bcl2) by SDS-PAGE
Select
E. coli
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
27.4kDa
10µg   $245.00; 50µg   $375.00; 200µg   $635.00; 100µg   $495.00; 1mg   $1,890.00; 500µg   $845.00

Viewing 1-25 of 25 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).