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BBC3 / PUMA

BCL2 binding component 3

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Gene Name: BCL2 binding component 3
Family/Subfamily: Apoptosis , not assigned-Apoptosis
Synonyms: BBC3, Bcl-2-binding component 3, BCL2 binding component 3, JFY-1, JFY1, PUMA, PUMA alpha
Target Sequences: NM_014417 NP_055232.1 Q9BXH1

Publications (2)

1
Aberrant activation of notch signaling in human breast cancer. Stylianou S, Clarke RB, Brennan K. Cancer research. 2006 66:1517-25. [PubMed:16452208]
2
Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Ernesto Diaz-Flores, Evan Q Comeaux, Kailyn L Kim, Ella Melnik, Kyle Beckman, Kara L Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S Braun, Charles G Mullighan, Mignon L Loh. Cancer research. 2019 May;79:2339-2351. [Full Text Article] [PubMed:30862722] [PMC:PMC6497548] Related Antibodies: LS-C98860.

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Products
ELISA Kits (20)
Competitive EIA (1)
Custom (3)
Sandwich (14)
Sandwich CLIA (2)
BBC3 / PUMA (20)
Human (6)
Mouse (2)
Rat (6)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (2)
96-Well Strip Plate (16)
No (20)
Cell Lysates (1)
Plasma (9)
Serum (9)
Tissue Homogenates (4)
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
BBC3 / PUMA ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
BBC3 / PUMA ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
BBC3 / PUMA ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
BBC3 / PUMA ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
BBC3 / PUMA ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$856
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
BBC3 / PUMA ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
BBC3 / PUMA ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
BBC3 / PUMA ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).