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BAX

BCL2-associated X protein

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.

Gene Name: BCL2-associated X protein
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: BAX, BCL2-associated X protein, Bcl2-L-4, Apoptosis regulator BAX, Bcl-2-like protein 4, BCL2L4
Target Sequences: NM_004324 NP_004315.1 Q07812

Publications (5)

1
Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Arduini A, Serviddio G, Escobar J, Tormos AM, Bellanti F, Via J, Monsalve M, Sastre J. American journal of physiology. Gastrointestinal and liver physiology. 2011 301:G119-27. [PubMed:21415417]
2
Potentilla reptans L. postconditioning protects reperfusion injury via the RISK/SAFE pathways in an isolated rat heart. Ayesheh Enayati #, Aref Salehi #, Mostafa Alilou, Hermann Stuppner, Mirali Polshekan, Maryam Rajaei, Mona Pourabouk, Ali Jabbari , Zohreh Mazaheri, Narguess Yassa, Hamid Reza Moheimani, Vahid Khori #. BMC complementary medicine and therapies. 2021 Nov;21:288. [Full Text Article] [PubMed:34823510] [PMC:PMC8620719] Related Antibodies: LS-C353915.
3
GANT61/BI-847325 combination: a new hope in lung cancer treatment. Abdel Halim M El-Kishky, Nermine Moussa, Maged W Helmy, Medhat Haroun. Medical oncology (Northwood, London, England). 2022 July;39:144. [Full Text Article] [PubMed:35834029] [PMC:PMC9283175]
4
Myricetin (3,3',4',5,5',7-Hexahydroxyflavone) Prevents 5-Fluorouracil-Induced Cardiotoxicity. Azher Arafah, Muneeb U Rehman, Ajaz Ahmad, Khalid M AlKharfy, Saeed Alqahtani, Basit L Jan, Nada M Almatroudi. ACS Omega. 2022 February;7:4514-4524. [Full Text Article] [PubMed:35155943] [PMC:PMC8829927]
5
LncRNA H19 aggravates TNF-a-induced inflammatory injury via TAK1 pathway in MH7A cells. Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia. BioFactors (Oxford, England). 2020 September;46:813-820. [Full Text Article] [PubMed:32525617]
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Proteins (14)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (8)
BAX (14)
No (14)
6His, N-terminus (2)
6His, N-terminus + 6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (2)
Myc-DDK (Flag) (5)
Human (8)
Mouse (3)
Pig (1)
293T Cells (2)
E. coli (5)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (2)
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E. coli
6His, N-terminus + 6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.1kD
10 µg/$316; 50 µg/$519; 500 µg/$1,627; 1 mg/$2,241
BAX Protein - Recombinant Bcl2 Associated X Protein (Bax) by SDS-PAGE
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E. coli
His, N-Terminal
25kDa
10 µg/$274; 50 µg/$400; 200 µg/$797; 100 µg/$637; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053
BAX Protein - Recombinant Bcl2 Associated X Protein By SDS-PAGE
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E. coli
His
22.9 kDa
10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
BAX Protein - 12.5% SDS-PAGE of human BAX stained with Coomassie Blue
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Wheat Germ Extract
GST
46.86 kDa
10 µg/$479; 25 µg/$670
BAX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
21 kDa
100 µg/$494
BAX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
15.6 kDa
100 µg/$494
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HEK 293 Cells
6His, N-terminus
19 kDa
200 µl/$283
Select
HEK 293 Cells
6His, N-terminus
19 kDa
100 µg/$298
BAX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21 kDa
20 µg/$150
BAX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
15.6 kDa
20 µg/$150
BAX Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BAX Protein - Purified recombinant protein BAX was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
21 kDa
20 µg/$1,107
Select
E. coli
6His, N-terminus + 6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.1 kDa
10 µg/$344; 50 µg/$584
BAX Protein - Recombinant Bcl2 Associated X Protein (Bax) by SDS-PAGE
Select
E. coli
His, N-Terminal
22.6kDa
10 µg/$288; 50 µg/$487; 200 µg/$972; 100 µg/$780; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).