BATF

basic leucine zipper transcription factor, ATF-like

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8+ dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8+ T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

BATF (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human BATF Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67166

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.9 kDa

Price:

20 µg/$1,107

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BATF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115327

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.9 kDa

Price:

100 µg/$494

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Human BATF Protein (Recombinant His) - LS-G1156

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human BATF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79266

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.9 kDa

Price:

20 µg/$150

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Human BATF Protein (Recombinant GST, N-terminus) (aa34-125) - LS-G61552

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human BATF Protein (Recombinant GST) (Full Length) - LS-G32209

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

40.5 kDa

Price:

10 µg/$479; 25 µg/$670

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