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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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BAP1

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

Gene Name: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Family/Subfamily: Protease , Cysteine C12
Synonyms: BAP1, BRCA1 binding protein BAP1, Cerebral protein 6, Hucep-6, UCHL2, BRCA1-associated protein 1, Cerebral protein-13, HUCEP-13, KIAA0272, TPDS
Target Sequences: NM_004656 NP_004647.1 Q92560

Publications (1)

1
Frequent mutation of BAP1 in metastasizing uveal melanomas. Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C, Bowcock AM. Science (New York, N.Y.). 2010 330:1410-3. [PubMed:21051595] [PMC:PMC3087380]

Filtered By: None
Target
BAP1 (44)
Reactivity
Human (44)
Mouse (19)
Rat (12)
Bat (4)
Bovine (5)
Chicken (6)
Chimpanzee (3)
Dog (6)
Gibbon (3)
Guinea pig (4)
Horse (5)
Monkey (4)
Orangutan (3)
Pig (4)
Rabbit (5)
Xenopus (5)
Zebrafish (5)
Application
IHC (15)
IHC-Fr (2)
IHC-P (8)
WB (41)
DB (2)
ELISA (18)
ICC (3)
IF (3)
IP (4)
PLA (1)
Host
rabbit (28)
mouse (16)
Isotype
IgG (22)
IgG1 (6)
IgG1,k (8)
Clonality
monoclonal mc (15)
polyclonal pc (29)
Clone
1G8 (6)
2058C3a (2)
BP-1 (3)
BSB-109 (2)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (4)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
Magnetic beads Conjugated (1)
PE Conjugated (2)
Ready-to-Use (1)
Sepharose Conjugated (1)
Unconjugated (23)
Epitope
N-Terminus (8)
aa699-729 (8)
C-Terminus (4)
aa337-440 (1)
aa460-729 (1)
aa500-550 (1)
aa679-729 (1)
Publications
No (44)
Showing 1-25 of 44 results

BAP1 Antibody (clone 1G8) IHC-plus™ LS-B4874
Mouse Monoclonal [clone 1G8] (IgG1,k) to Human BAP1
Human
IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $425.00
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BAP1 Antibody (clone 1G8, Biotin) LS-C141679
Mouse Monoclonal [clone 1G8] (IgG1,k) to Human BAP1
Human
IHC IHC-P WB
Biotin Conjugated
100µl  $365.00
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BAP1 Antibody (clone 1G8, DY650) LS-C141680
Mouse Monoclonal [clone 1G8] (IgG1,k) to Human BAP1
Human
IHC IHC-P WB
DY650 Conjugated
100µl  $365.00
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BAP1 Antibody (clone 1G8, DY488) LS-C141681
Mouse Monoclonal [clone 1G8] (IgG1,k) to Human BAP1
Human
IHC IHC-P WB
DY488 Conjugated
100µl  $365.00
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BAP1 Antibody (clone 1G8, DY550) LS-C141683
Mouse Monoclonal [clone 1G8] (IgG1,k) to Human BAP1
Human
IHC IHC-P WB
DY550 Conjugated
100µl  $365.00
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-BAP1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

BAP1 Antibody (clone 1G8) LS-C74637
Mouse Monoclonal [clone 1G8] (IgG1,k) to Human BAP1
Human
WB
Unconjugated
100µl 1mg/ml  $530.00

BAP1 Antibody (N-Terminus) LS-C99602
Rabbit Polyclonal to Human BAP1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
400µl  $305.00

BAP1 Antibody (clone BP-1) LS-C171039
Mouse Monoclonal [clone BP-1] (IgG1) to Human BAP1
Human
ICC WB
Unconjugated
100µg 1ml 1mg/ml  $295.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

BAP1 Antibody (clone BP-1, Magnetic beads) LS-C171040
Mouse Monoclonal [clone BP-1] (IgG1) to Human BAP1
Human
IP WB
Magnetic beads Conjugated
100µg 1mg/ml  $325.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

BAP1 Antibody (clone 2058C3a) LS-C342481
Mouse Monoclonal [clone 2058C3a] (IgG1) to Human BAP1
Human
DB ICC IF WB
Unconjugated
100µg 0.1mg/ml  $375.00
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-BAP1 mAb.
Western blot analysis of immunized recombinant protein, using anti-BAP1 monoclonal antibody.
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-BAP1 mAb.
Western blot analysis of immunized recombinant protein, using anti-BAP1 monoclonal antibody.

BAP1 Antibody LS-C334779
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded Human mammary gland tissue.
Immunofluorescence analysis of HeLa cells.
Immunohistochemistry of paraffin-embedded Human mammary gland tissue.
Immunofluorescence analysis of HeLa cells.

BAP1 Antibody LS-C404674
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human ovarian cancer using BAP1 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human colon cancer using BAP1 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human ovarian cancer using BAP1 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human colon cancer using BAP1 Polyclonal Antibody at dilution of 1:40.

BAP1 Antibody (N-Terminus) LS-C326913
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Human
ELISA IHC WB
Unconjugated
200µl 0.25mg/ml  $530.00

BAP1 Antibody (N-Terminus, Biotin) LS-C275416
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

BAP1 Antibody (N-Terminus, FITC) LS-C275417
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

BAP1 Antibody (N-Terminus, APC) LS-C275413
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

BAP1 Antibody (N-Terminus, PE) LS-C275419
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

BAP1 Antibody (N-Terminus, AP) LS-C275412
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

BAP1 Antibody (N-Terminus, Azide-free, HRP) LS-C275418
Rabbit Polyclonal (IgG) to Human BAP1
Mouse, Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

BAP1 Antibody (clone 2058C3a) LS-C184439
Mouse Monoclonal [clone 2058C3a] (IgG1) to Human BAP1
Human
DB ICC WB
Unconjugated
50µg 0.1mg/ml  $325.00
Western blot of immunized recombinant protein using BAP1 antibody.
Western blot of immunized recombinant protein using BAP1 antibody.

BAP1 Antibody (aa679-729) LS-C288997
Rabbit Polyclonal (IgG) to Human BAP1
Xenopus, Chicken, Zebrafish, Rat, Mouse, Dog, Human
IP PLA WB
Unconjugated
100µl 1mg/ml  $395.00

BAP1 Antibody (aa699-729) LS-C326912
Rabbit Polyclonal (IgG) to Human BAP1
Human
ELISA WB
Unconjugated
200µl 0.25mg/ml  $530.00

BAP1 Antibody LS-C659897
Rabbit Polyclonal (IgG) to Human BAP1
Human
ELISA WB
Unconjugated
100µg  $435.00

BAP1 Antibody LS-C306498
Mouse Polyclonal (IgG) to Human BAP1
Human
IF WB
Unconjugated
50µg  $560.00

BAP1 Antibody (aa460-729) LS-C378849
Rabbit Polyclonal (IgG) to Human BAP1
Human
ELISA WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Western blot. All lanes: Protein BANP antibody at 8 ug/ml+HeLa whole cell lysate. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 80 kDa. Observed band size: 80 kDa.
Western blot. All lanes: Protein BANP antibody at 8 ug/ml+HeLa whole cell lysate. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 80 kDa. Observed band size: 80 kDa.
Showing 1-25 of 44 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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