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BANK1 / BANK is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
Gene Name: | B-cell scaffold protein with ankyrin repeats 1 |
Synonyms: | BANK1, BANK |
Target Sequences: | NM_017935 |
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