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BAG6 / G3 / Scythe

BCL2-associated athanogene 6

Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Moreover, it regulates the stability and the degradation of proteins by the proteasome. For instance, it is required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. It is also involved in ubiquitin-mediated proteasomal degradation of proteins of the secretory pathway that are mislocalized to the cytosol. Binds the mislocalized proteins, preventing their aggregation in the cytosol, and promotes their ubiquitination. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2.

Gene Name: BCL2-associated athanogene 6
Synonyms: BAG6, BCL2-associated athanogene 6, D6S52E, HLA-B associated transcript 3, HLA-B-associated transcript 3, HLA-B associated transcript-3, G3, Protein G3, Protein Scythe, Scythe, BAG-6, BAT3
Target Sequences: NM_004639 NP_004630.3 P46379

☰ Filters
Antibodies (33)
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BAG6 / G3 / Scythe (55)
Human (35)
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BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-10 ug/ml.
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BAG6 / G3 / Scythe Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
BAG6 / G3 / Scythe Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa200-250) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
BAG6 / G3 / Scythe Antibody - IHC staining of FFPE rat lung with BAG6 antibody at 1ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, Flo, IF, IHC-P, WB
Unconjugated
100 µg/$575
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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BAG6 / G3 / Scythe Goat anti-Human Polyclonal (aa257-270) Antibody
Dog, Bovine, Pig, Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa943-992) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa943-992) (HRP) Antibody
Human, Monkey, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa943-992) (Biotin) Antibody
Human, Monkey, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa943-992) (FITC) Antibody
Human, Monkey, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
BAG6 / G3 / Scythe Antibody - Anti-BAG6 / G3 / Scythe antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
BAG6 / G3 / Scythe Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.
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BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa1-200) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
BAG6 / G3 / Scythe Antibody - Western blot analysis of extract of various cells.
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BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa1072-1099) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa1072-1099) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa1072-1099) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa1072-1099) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa1072-1099) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa1072-1099) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
BAG6 / G3 / Scythe Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal (aa1082-1132) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Select
BAG6 / G3 / Scythe Mouse anti-Human Monoclonal (2B9) Antibody
Human
ELISA
Unconjugated
200 µl/$423
Select
BAG6 / G3 / Scythe Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Viewing 1-25 of 55 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).