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Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc4Cer; paragloboside), resulting in the synthesis of Lc3Cer and neolactopentaosylceramide (nLc5Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Gene Name: | Udp-glcnac:betagal Beta-1,3-n-acetylglucosaminyltransferase 5 |
Synonyms: | B3GNT5, Beta-1,3-Gn-T5, Lc(3)Cer synthase, Lc3 synthase, B3GN-T5, Beta3Gn-T5, BGnT-5, Lactotriaosylceramide synthase |
Target Sequences: | NM_032047 NP_114436.1 Q9BYG0 |
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