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AXIN1 / Axin-1

axin 1

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

Gene Name: axin 1
Synonyms: AXIN1, Axis inhibitor 1, AXIN, Axin 1, Axis inhibition protein 1, Fused, mouse, homolog of, HAxin, PPP1R49, Axin-1
Target Sequences: AF009674 AAC51624.1 O15169

☰ Filters
Products
Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
AXIN1 / Axin-1 (9)
No (9)
6His, N-terminus (1)
GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (5)
Human (5)
Mouse (1)
Rat (1)
293T Cells (2)
E. coli (3)
HEK 293 Cells (3)
Wheat Germ Extract (1)
AXIN1 / Axin-1 Protein - Recombinant Axis Inhibition Protein By SDS-PAGE
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E. coli
6His, N-terminus
27.2 kDa
10 µg/$269; 50 µg/$408; 100 µg/$648; 200 µg/$810; 1 mg/$1,828
AXIN1 / Axin-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
95.5 kDa
20 µg/$200
AXIN1 / Axin-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
91.5 kDa
20 µg/$130
AXIN1 / Axin-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
91.5 kDa
100 µg/$458
AXIN1 / Axin-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
95.5 kDa
100 µg/$607
AXIN1 / Axin-1 Protein - Purified recombinant protein AXIN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
91.5 kDa
20 µg/$1,024
AXIN1 / Axin-1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$461; 25 µg/$611
AXIN1 / Axin-1 Protein - Recombinant Axis Inhibition Protein By SDS-PAGE
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E. coli
His-T7
27.4 kDa
10 µg/$277; 50 µg/$458; 100 µg/$731; 200 µg/$912; 1 mg/$2,006
AXIN1 / Axin-1 Protein - Recombinant Axis Inhibition Protein By SDS-PAGE
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E. coli
His-T7
27.6 kDa
10 µg/$271; 50 µg/$422; 100 µg/$674; 200 µg/$841; 1 mg/$1,880
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).