LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us

ATRX

alpha thalassemia/mental retardation syndrome X-linked

Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomers. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according (PubMed:24500201) is not sufficient to decrease chromatin condensation at telomers nor to increase expression of telomeric RNA in fibroblasts. May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone H2AFY, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis.

Gene Name: alpha thalassemia/mental retardation syndrome X-linked
Synonyms: ATRX, ATP-dependent helicase ATRX, ATR2, Juberg-Marsidi syndrome, JMS, RAD54, RAD54 homolog, SFM1, MRXHF1, XH2, XNP, Transcriptional regulator ATRX, ZNF-HX, X-linked nuclear protein, SHS, Helicase 2, X-linked, X-linked helicase II, Zinc finger helicase
Target Sequences: NM_000489 NP_000480.3 P46100

Publications (1)

1
BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54. Srivastava V, Modi P, Tripathi V, Mudgal R, De S, Sengupta S. Journal of cell science. 2009 122:3093-103. [PubMed:19671661] [PMC:PMC2729260]

Filtered By: None
Target
ATRX (22)
Reactivity
Human (22)
Mouse (5)
Rat (2)
Chimpanzee (3)
Dog (5)
Gibbon (3)
Guinea pig (1)
Monkey (2)
Orangutan (3)
Pig (3)
Rabbit (7)
Sheep (1)
Application
IHC (4)
IHC-Fr (2)
IHC-P (6)
WB (9)
ELISA (7)
ICC (2)
IF (6)
IHC-Fx (2)
IP (1)
Peptide-ELISA (2)
PLA (1)
SDS-PAGE (2)
Host
rabbit (16)
mouse (5)
goat (1)
Isotype
IgG (11)
IgG1 (2)
IgG1,k (1)
IgG2a,k (2)
Clonality
monoclonal mc (5)
polyclonal pc (15)
recombinant monoclonal rmc (2)
Clone
3C9 (1)
8B2H9 (1)
ATRX/2900R (2)
BSB-108 (2)
Rad544E3/1 (1)
Format
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Ready-to-Use (1)
Unconjugated (16)
Epitope
aa904-953 (4)
C-Terminus (2)
80-160 aa, N-terminal (1)
aa111-160 (1)
aa2161-2443 (1)
aa970-984 (1)
Publications
No (22)
Showing 1-22 of 22 results

ATRX Antibody (aa2161-2443) LS-C185396
Rabbit Polyclonal (IgG) to Human ATRX
Human
ICC IHC IHC-P WB
Unconjugated
100µl 1.16mg/ml  $335.00
IHC of paraffin-embedded A549 xenograft using ATRX antibody at 1:100 dilution.
Immunofluorescence of paraformaldehyde-fixed HeLa using ATRX antibody at 1:200 dilution.
IHC of paraffin-embedded A549 xenograft using ATRX antibody at 1:100 dilution.
Immunofluorescence of paraformaldehyde-fixed HeLa using ATRX antibody at 1:200 dilution.

ATRX Antibody (C-Terminus) LS-C287876
Rabbit Polyclonal (IgG) to Human ATRX
Rabbit, Pig, Human
IF IHC IHC-P IP PLA WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human ATRX by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-ATRX used at a dilution of 1:1000 (1 ug/ml).
Detection of Human ATRX by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-ATRX used at a dilution of 1:1000 (1 ug/ml).

ATRX Antibody (clone Rad544E3/1) LS-C63157
Mouse Monoclonal [clone Rad544E3/1] (IgG1) to Human ATRX
Rabbit, Dog, Guinea pig, Sheep, Pig, Human, Monkey
WB
Unconjugated
25µg 0.95mg/ml  $245.00; 100µg  $355.00

ATRX Antibody LS-C677256
Rabbit Polyclonal (IgG) to Human ATRX
Human
ELISA IF IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human kidney tissue at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer at dilution of 1:100

ATRX Antibody (HRP) LS-C677257
Rabbit Polyclonal (IgG) to Human ATRX
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

ATRX Antibody (Biotin) LS-C677254
Rabbit Polyclonal (IgG) to Human ATRX
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

ATRX Antibody (FITC) LS-C677253
Rabbit Polyclonal (IgG) to Human ATRX
Human
ELISA
FITC Conjugated
50µg  $285.00; 100µg  $385.00

ATRX Antibody (C-Terminus) LS-C286484
Rabbit Polyclonal (IgG) to Human ATRX
Rabbit, Pig, Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human ATRX by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-ATRX used at a dilution of 1:250.
Detection of Human ATRX by Immunohistochemistry. Sample: FFPE section of human basal cell carcinoma. Antibody: Affinity purified rabbit anti-ATRX used at a dilution of 1:250.
Detection of Human ATRX by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-ATRX used at a dilution of 1:250.
Detection of Human ATRX by Immunohistochemistry. Sample: FFPE section of human basal cell carcinoma. Antibody: Affinity purified rabbit anti-ATRX used at a dilution of 1:250.

ATRX Antibody LS-C416080
Rabbit Polyclonal to Human ATRX
Mouse, Human
ICC IF
Unconjugated
100µg 1mg/ml  $305.00

ATRX Antibody (clone 8B2H9) LS-C682492
Mouse Monoclonal [clone 8B2H9] (IgG1) to Human ATRX
Human
ELISA WB
Unconjugated
100µl  $365.00
Western blot analysis using ATRX mAb against human ATRX (AA: 2311-2492) recombinant protein. (Expected MW is 46.6 kDa)
Western blot analysis using ATRX mAb against HEK293 (1) and ATRX (AA: 2311-2492)-hIgGFc transfected HEK293 (2) cell lysate.
Western blot analysis using ATRX mAb against human ATRX (AA: 2311-2492) recombinant protein. (Expected MW is 46.6 kDa)
Western blot analysis using ATRX mAb against HEK293 (1) and ATRX (AA: 2311-2492)-hIgGFc transfected HEK293 (2) cell lysate.

ATRX Antibody (80-160 aa, N-terminal) LS-C382211
Rabbit Polyclonal (IgG) to Human ATRX
Mouse, Human
ELISA IF
Unconjugated
100µl 1mg/ml  $265.00

ATRX Antibody (clone 3C9) LS-C196726
Mouse Monoclonal [clone 3C9] (IgG1,k) to Human ATRX
Human
ELISA WB
Unconjugated
100µg  $355.00
Detection limit for recombinant GST tagged ATRX is approximately 0.1 ng/ml as a capture antibody.
Detection limit for recombinant GST tagged ATRX is approximately 0.1 ng/ml as a capture antibody.

ATRX Antibody (aa111-160) LS-C118900
Rabbit Polyclonal (IgG) to Human ATRX
Mouse, Human
IF Peptide-ELISA
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunofluorescence analysis of A549 cells, using ATRX Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of A549 cells, using ATRX Antibody. The picture on the right is blocked with the synthesized peptide.

ATRX Antibody (clone BSB-108, Ready-to-Use) LS-C743503
Mouse Monoclonal [clone BSB-108] (IgG2a,k) to Human ATRX
Mouse, Rat, Human
IHC-Fr IHC-P
Unconjugated, Ready-to-Use
3ml  $235.00; 7ml  $295.00; 15ml  $415.00

ATRX Antibody (clone BSB-108) LS-C743620
Mouse Monoclonal [clone BSB-108] (IgG2a,k) to Human ATRX
Mouse, Rat, Human
IHC-Fr IHC-P
Unconjugated
0.1ml  $275.00; 0.5ml  $425.00; 1ml  $605.00

ATRX Antibody (aa904-953) LS-C201544
Rabbit Polyclonal to Human ATRX
Rabbit, Dog, Human
WB
Unconjugated
50µg  $365.00
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ATRX Antibody (aa904-953, HRP) LS-C450455
Rabbit Polyclonal to Human ATRX
Rabbit, Dog, Human, Chimpanzee, Orangutan, Gibbon
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ATRX Antibody (aa904-953, Biotin) LS-C450453
Rabbit Polyclonal to Human ATRX
Rabbit, Dog, Human, Chimpanzee, Orangutan, Gibbon
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ATRX Antibody (aa904-953, FITC) LS-C450454
Rabbit Polyclonal to Human ATRX
Rabbit, Dog, Human, Chimpanzee, Orangutan, Gibbon
WB
FITC Conjugated
100µl 1mg/ml  $385.00
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ATRX Antibody (clone ATRX/2900R) LS-C751315
Rabbit Recombinant Monoclonal [clone ATRX/2900R] (IgG) to Human ATRX
Human
IHC-Fx SDS-PAGE
Unconjugated
100µg 1mg/ml  $465.00
Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R).
SDS-PAGE Analysis Purified ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R).
SDS-PAGE Analysis Purified ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R). Confirmation of Purity and Integrity of Antibody.

ATRX Antibody (clone ATRX/2900R) LS-C751314
Rabbit Recombinant Monoclonal [clone ATRX/2900R] (IgG) to Human ATRX
Human
IHC-Fx SDS-PAGE
Unconjugated
20µg 200µg/ml  $295.00; 100µg 200µg/ml  $465.00
Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R).
SDS-PAGE Analysis Purified ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R).
SDS-PAGE Analysis Purified ATRX Rabbit Recombinant Monoclonal Antibody (ATRX/2900R). Confirmation of Purity and Integrity of Antibody.

ATRX Antibody (aa970-984) LS-C305834
Goat Polyclonal to Human ATRX
Human, Monkey
Peptide-ELISA
Unconjugated
100µg 0.5mg/ml  $335.00
Showing 1-22 of 22 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Get Social With Us!
Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy