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ATPIF1 / ATPI
ATPase inhibitory factor 1
Endogenous F1F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F1F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F1F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
| Gene Name: | ATPase inhibitory factor 1 |
| Synonyms: | ATPIF1, ATPIP, ATPase inhibitor protein, ATPase inhibitory factor 1, ATPI, IF1, ATP synthase inhibitor protein, IF(1), Inhibitor of F(1)F(o)-ATPase, IP |
| Target Sequences: | NM_016311 NP_057395.1 Q9UII2 |
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