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ATP6V1G1 / ATP6J
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATP6V1G1 / ATP6J is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized.
| Gene Name: | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 |
| Family/Subfamily: | Transporter , ATPase - V type |
| Synonyms: | ATP6V1G1, ATP6GL, ATP6J, Atp1v1g1, ATP6G, ATP6G1, V-ATPase 13 kDa subunit 1, V-ATPase G subunit 1, Vma10, V-ATPase subunit G 1 |
| Target Sequences: | NM_004888 NP_004879.1 O75348 |
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