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ATP2B4 / PMCA4

ATPase, Ca++ transporting, plasma membrane 4

ATP2B4 / PMCA4 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: ATPase, Ca++ transporting, plasma membrane 4
Family/Subfamily: Transporter , ATPase - P type, type IIB
Synonyms: ATP2B4, HPMCA4, PMCA4b, PMCA4x, Sarcolemmal calcium pump, MXRA1, PMCA4
Target Sequences: NM_001684 NP_001675.3 P23634

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
ATP2B4 / PMCA4 (4)
No (4)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
ATP2B4 / PMCA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
133.8 kDa
20 µg/$215
ATP2B4 / PMCA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
133.8 kDa
100 µg/$710
ATP2B4 / PMCA4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ATP2B4 / PMCA4 Protein - Purified recombinant protein ATP2B4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
133.8 kDa
20 µg/$1,107
Viewing 1-4 of 4 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).