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ATP2B3 / PMCA3

ATPase, Ca++ transporting, plasma membrane 3

ATP2B3 / PMCA3 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: ATPase, Ca++ transporting, plasma membrane 3
Family/Subfamily: Transporter , ATPase - P type, type IIB
Synonyms: ATP2B3, Plasma membrane calcium ATPase, Plasma membrane calcium pump, PMCA3, PMCA3a
Target Sequences: NM_021949 NP_068768.2 Q16720

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Proteins (2)
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ATP2B3 / PMCA3 (2)
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HEK 293 Cells (1)
ATP2B3 / PMCA3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
134 kDa
100 µg/$710
ATP2B3 / PMCA3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
134 kDa
20 µg/$215
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).