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ATP2B2 / PMCA2
ATPase, Ca++ transporting, plasma membrane 2
ATP2B2 / PMCA2 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.
| Gene Name: | ATPase, Ca++ transporting, plasma membrane 2 |
| Family/Subfamily: | Transporter , ATPase - P type, type IIB |
| Synonyms: | ATP2B2, PMCA2, Plasma membrane calcium ATPase, PMCA2i, Plasma membrane Ca2+ pump 2, Plasma membrane calcium pump, Plasma membrane Ca(2+)-ATPase, PMCA2a |
| Target Sequences: | NM_001683 NP_001674.2 Q01814 |
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