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Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
Gene Name: | WD repeat domain, phosphoinositide interacting 1 |
Synonyms: | WIPI1, ATG18, Atg18 protein homolog, ATG18A, WIPI49, WIPI-1, WIPI 49 kDa, WIPI-1 alpha |
Target Sequences: | Q5MNZ9 Q5MNZ9 |
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