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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ATF2

activating transcription factor 2

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

Gene Name: activating transcription factor 2
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: ATF2, CREB-2, CRE-BP1, CREB2, HB16, TREB7, CREBP1
Target Sequences: NM_001880 NP_001871.2 P15336

Publications (1)

1
Dephosphorylation of beta-arrestin 1 in glioblastomas. Mandell JW, Glass G, Gianchandani EP, Locke CN, Amos S, Bourne TD, Schiff D, Papin JA. Journal of neuropathology and experimental neurology. 2009 68:535-41. (IHC, WB) [PubMed:19404096]

Filtered By: None
Target
ATF2 (156)
Reactivity
Human (148)
Mouse (75)
Rat (75)
Bat (8)
Bovine (18)
Chicken (21)
Chimpanzee (6)
Dog (9)
Gibbon (6)
Guinea pig (6)
Hamster (8)
Horse (13)
Monkey (16)
Non-Human Primate (1)
Pig (5)
Rabbit (15)
Xenopus (8)
Zebrafish (6)
Application
IHC (92)
IHC-Fr (1)
IHC-P (43)
WB (144)
Flo (2)
DB (10)
ELISA (52)
Func (1)
ICC (3)
IF (21)
IP (42)
Peptide-ELISA (15)
PLA (1)
Host
rabbit (131)
mouse (16)
goat (1)
sheep (8)
Isotype
IgG (97)
IgG1 (6)
IgG1,k (9)
Clonality
monoclonal mc (15)
polyclonal pc (141)
Clone
103C411.2 (2)
1E12 (1)
4A3 (1)
4F12 (1)
ATF25I062 (2)
Format
AP Conjugated (5)
APC Conjugated (5)
Azide-free (4)
Biotin Conjugated (8)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (5)
Unconjugated (117)
Epitope
pSer322 (8)
pSer480 (8)
aa317-347 (7)
pSer90 (7)
10-90 aa (6)
N-Terminus (5)
C-Terminus (4)
aa401-450 (4)
aa51-100 (4)
pThr71 (4)
pSer112 (3)
pThr73 (3)
40-120 aa (2)
410-490 aa (2)
430-510 aa (2)
50-130 aa (2)
Internal (2)
pSer472 (2)
pSer498 (2)
pSer62 (2)
pThr53 (2)
pThr69 (2)
pThr69/Thr51 (2)
pThr71/Thr53 (2)
Asp67/49 (1)
Gly56/39 (1)
Ser112/Ser94 (1)
Ser62 (1)
Thr51 (1)
Val63/45 (1)
Val65/47 (1)
aa13-27 (1)
aa250-300 (1)
aa29-78 (1)
aa35-84 (1)
aa38-87 (1)
aa40-89 (1)
aa437-487 (1)
aa441-490 (1)
aa456-505 (1)
aa492-505 (1)
aa79-128 (1)
aa93-450 (1)
pSer112/94 (1)
pSer490/Ser498 (1)
pSer62/44 (1)
pSer62/Ser44 (1)
pThr52 (1)
pThr69/51 (1)
pThr69/71 (1)
pThr69/Thr71 (1)
pThr71/53 (1)
pThr73/ 55 (1)
pThr73/Thr55 (1)
Publications
No (156)
Publications
Showing 1-25 of 156 results

ATF2 Antibody (clone 4A3) IHC-plus™ LS-B6524
Mouse Monoclonal [clone 4A3] (IgG1,k) to Human ATF2
Human
ELISA IHC IHC-P WB
Unconjugated
50µg 0.34mg/ml  $485.00
Anti-ATF2 antibody IHC of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-ATF2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-ATF2 antibody IHC of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-ATF2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

ATF2 Antibody (clone 4F12) LS-C169314
Mouse Monoclonal [clone 4F12] (IgG1) to Human ATF2
Human
ELISA IHC IHC-P WB
Unconjugated
100µl  $365.00
IHC of paraffin-embedded lung cancer (left) and brain tissues (right) using ATF2 mouse monoclonal antibody with DAB staining.
Western blot using ATF2 mouse monoclonal antibody against NIH/3T3 cell lysate.
IHC of paraffin-embedded lung cancer (left) and brain tissues (right) using ATF2 mouse monoclonal antibody with DAB staining.
Western blot using ATF2 mouse monoclonal antibody against NIH/3T3 cell lysate.

ATF2 Antibody (Ser62) IHC-plus™ LS-B1170
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-ATF2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Immunofluorescence staining of methanol-fixed HeLa cells using ATF2(Ab-62 or 44) antibody.
Anti-ATF2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Immunofluorescence staining of methanol-fixed HeLa cells using ATF2(Ab-62 or 44) antibody.

ATF2 Antibody (aa401-450) LS-C31200
Rabbit Polyclonal (IgG) to Human ATF2
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Human, Monkey
IHC IHC-P WB
Unconjugated
100µg  $325.00
ATF2 antibody ARP34151_T100-NP_001871-ATF2 (activating transcription factor 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ATF2 antibody ARP34151_T100-NP_001871-ATF2 (activating transcription factor 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ATF2 antibody ARP34151_T100-NP_001871-ATF2 (activating transcription factor 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ATF2 antibody ARP34151_T100-NP_001871-ATF2 (activating transcription factor 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ATF2 Antibody LS-C306429
Mouse Monoclonal (IgG1,k) to Human ATF2
Human
ELISA IF IHC IHC-P WB
Unconjugated
100µg  $560.00

ATF2 Antibody (Biotin) LS-C520858
Mouse Monoclonal (IgG1,k) to Human ATF2
Human
ELISA IF IHC WB
Biotin Conjugated
100µl  $710.00

ATF2 Antibody (FITC) LS-C530902
Mouse Monoclonal (IgG1,k) to Human ATF2
Human
ELISA IF IHC WB
FITC Conjugated
100µl  $710.00

ATF2 Antibody (PE) LS-C649103
Mouse Monoclonal (IgG1,k) to Human ATF2
Human
ELISA IF IHC WB
PE Conjugated
100µl  $710.00

ATF2 Antibody (APC) LS-C512643
Mouse Monoclonal (IgG1,k) to Human ATF2
Human
ELISA IF IHC WB
APC Conjugated
100µl  $710.00

ATF2 Antibody (phospho-Ser480) LS-C198650
Rabbit Polyclonal (IgG) to Human ATF2
Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using ATF2 (Phospho-Ser480) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of HeLa cells, using ATF2 (Phospho-Ser480) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using ATF2 (Phospho-Ser480) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of HeLa cells, using ATF2 (Phospho-Ser480) Antibody. The picture on the right is blocked with the phospho peptide.

ATF2 Antibody (430-510 aa) LS-C381508
Rabbit Polyclonal (IgG) to Human ATF2
Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00

ATF2 Antibody (phospho-Thr73/Thr55) LS-C34028
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $355.00
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using ATF2(Phospho-Thr73 or 55) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence staining of methanol-fixed HeLa cells using ATF2(Phospho-Thr73 or 55) antibody.
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using ATF2(Phospho-Thr73 or 55) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence staining of methanol-fixed HeLa cells using ATF2(Phospho-Thr73 or 55) antibody.

ATF2 Antibody LS-C659412
Rabbit Polyclonal (IgG) to Human ATF2
Human
ELISA IF IHC WB
Unconjugated
100µg  $435.00

ATF2 Antibody LS-C331946
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded human normal breast.
Immunohistochemistry of paraffin-embedded human breast cancer tissue.
Immunohistochemistry of paraffin-embedded human normal breast.
Immunohistochemistry of paraffin-embedded human breast cancer tissue.

ATF2 Antibody (Thr51) IHC-plus™ LS-B1171
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-ATF2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of extracts from LOVO cells using ATF2(Ab-69 or 51) antibody and the same antibody preincubated with blocking peptide.
Anti-ATF2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of extracts from LOVO cells using ATF2(Ab-69 or 51) antibody and the same antibody preincubated with blocking peptide.

ATF2 Antibody (phospho-Thr71) LS-C3468
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human
ELISA ICC IHC IHC-P IP WB
Unconjugated
100µl 0.025mg/ml  $575.00

ATF2 Antibody (aa93-450) LS-C343993
Rabbit Polyclonal to Human ATF2
Mouse, Rat, Human
IHC IHC-Fr IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $325.00
ATF2 antibody IHC-paraffin: Human Intestinal Cancer Tissue.
ATF2 antibody IHC-paraffin: Mouse Brain Tissue.
ATF2 antibody IHC-paraffin: Human Intestinal Cancer Tissue.
ATF2 antibody IHC-paraffin: Mouse Brain Tissue.

ATF2 Antibody LS-C408245
Rabbit Polyclonal (IgG) to Human ATF2
Human
ICC IHC IP WB
Unconjugated
50µl  $315.00; 100µl  $425.00; 200µl  $650.00
Western blot analysis of extracts of HeLa cells, using ATF2 antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
Western blot analysis of extracts of HeLa cells, using ATF2 antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.

ATF2 Antibody (phospho-Thr69) LS-C335801
Rabbit Polyclonal (IgG) to Human ATF2
IF IHC WB
Unconjugated
50µl  $265.00; 100µl  $375.00; 200µl  $495.00
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
Immunofluorescence staining of methanol-fixed Hela cells.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
Immunofluorescence staining of methanol-fixed Hela cells.

ATF2 Antibody (10-90 aa) LS-C380633
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human
ELISA IHC IP WB
Unconjugated
100µl 1mg/ml  $265.00

ATF2 Antibody (10-90 aa) LS-C382182
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human
ELISA IHC IP WB
Unconjugated
100µl 1mg/ml  $265.00

ATF2 Antibody (10-90 aa) LS-C382202
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human, Monkey
ELISA IHC IP WB
Unconjugated
100µl 1mg/ml  $265.00

ATF2 Antibody (50-130 aa) LS-C382206
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human
ELISA IHC IP WB
Unconjugated
100µl 1mg/ml  $265.00

ATF2 Antibody LS-C483621
Rabbit Polyclonal to Human ATF2
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

ATF2 Antibody (phospho-Thr69/Thr71) LS-C3470
Rabbit Polyclonal (IgG) to Human ATF2
Mouse, Rat, Human
ELISA IHC IHC-P WB
Unconjugated
100µl  $575.00
Showing 1-25 of 156 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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