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ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

ASPM is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
Synonyms: ASPM, Asp homolog, Calmbp1, MCPH5, ASP
Target Sequences: NM_018136 BAA91676.1 Q8IZT6

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).