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ASF1A
anti-silencing function 1A histone chaperone
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
| Gene Name: | anti-silencing function 1A histone chaperone |
| Synonyms: | ASF1A, Anti-silencing function 1A, CCG1-interacting factor A, CIA, HAsf1, Histone chaperone ASF1A, HSPC146, HCIA, CGI-98, DKFZP547E2110, HAsf1a |
| Target Sequences: | NM_014034 NP_054753.1 Q9Y294 |
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