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ARL4D

ADP-ribosylation factor-like 4D

A gene encoding a low-molecular-weight GTP-binding protein was isolated and mapped to human chromosome 17q12-q21. Comparison of the predicted protein with the protein databases revealed striking homology to the family of ADP-ribosylation factors (ARFs), which are thought to be involved in membrane trafficking and protein secretion (Smith et al., 1995). In situ hybridization analysis of the gerbil homologue of human ADP-ribosylation factor 4L(ARF4L)indicated that the expression of ARF4L mRNA was elevated in neurons of the dentate gyrus (DG) and CA1 regions ( Katayama et al., 1998).

Gene Name:	ADP-ribosylation factor-like 4D
Family/Subfamily:	Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms:	ARL4D, ADP-ribosylation factor-like 6, ADP-ribosylation factor 4-like, ARF4L
Target Sequences:	NM_001661 NP_001652.2 P49703

Publications (1)

Immune related endonucleases and GTPases are not associated with tumor response in patients with advanced non-small cell lung cancer treated with checkpoint inhibitors. H O Ramdani, M Falk, L C Heukamp, S Schatz, M Tiemann, C Wesseler, L Diehl, E Schuuring, H J M Groen, F Griesinger. Pathology, research and practice. 2021 November;227:153651. [Full Text Article] [PubMed:34673351] Related Antibodies: LS-C369269.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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