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ARL2BP / BART
ADP-ribosylation factor-like 2 binding protein
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity.
| Gene Name: | ADP-ribosylation factor-like 2 binding protein |
| Synonyms: | ARL2BP, Binder of Arl Two, BART, BART1, Binder of ARF2 protein 1, ARF-like 2-binding protein, Binder of Arl2 |
| Target Sequences: | NM_012106 NP_036238.1 Q9Y2Y0 |
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