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ARL2

ADP-ribosylation factor-like 2

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca2+-dependent release of acetylcholine. Required for normal progress through the cell cycle.

Gene Name: ADP-ribosylation factor-like 2
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: ARL2, ARFL2, ADP-ribosylation factor-like 2
Target Sequences: NM_001667 NP_001658.2 P36404

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
ARL2 (6)
No (6)
GST (2)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
ARL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.7 kDa
100 µg/$494
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E. coli
GST
46.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ARL2 Protein - 12.5% SDS-PAGE of human ARL2 stained with Coomassie Blue
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Wheat Germ Extract
GST
45.98 kDa
2 µg/$439
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293T Cells
Myc-DDK (Flag)
20.7 kDa
20 µg/$150
ARL2 Protein - Purified recombinant protein ARL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.7 kDa
20 µg/$1,107
ARL2 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).