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ARID1A / BAF250

AT rich interactive domain 1A (SWI-like)

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Gene Name: AT rich interactive domain 1A (SWI-like)
Synonyms: ARID1A, BAF250, BAF250a, BRG1-associated factor 250a, C1orf4, BRG1-associated factor 250, ELD, HOSA1, Osa homolog 1, OSA1, OSA1 nuclear protein, SMARCF1, MRD14, p270, B120, BM029, Brain protein 120, C10rf4, HELD, SWI-like protein, SWI/SNF complex protein p270
Target Sequences: NM_006015 NP_006006.3 O14497

Publications (1)

1
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer. Sun X, Wang SC, Wei Y, Luo X, Jia Y, Li L, Gopal P, Zhu M, Nassour I, Chuang JC, Maples T, Celen C, Nguyen LH, Wu L, Fu S, Li W, Hui L, Tian F, Ji Y, Zhang S, Sorouri M, Hwang TH, Letzig L, James L, Wang Z, Yopp AC, Singal AG, Zhu H. Cancer cell. 2017 November;32:574-589. [Full Text Article] [PubMed:29136504] [PMC:PMC5728182] Related Antibodies: LS-C287870.

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Antibodies (19)
Primary (19)
ARID1A / BAF250 (19)
Human (17)
Mouse (6)
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rabbit (17)
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monoclonal mc (2)
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aa1021-1053 (1)
aa1717-1750 (1)
aa1930-1964 (1)
aa1986-2285 (1)
aa675-725 (1)
aa750-800 (1)
aa95-108 (1)
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ARID1A / BAF250 Antibody - Detection of Human ARID1A by Western Blot. Samples: Whole cell lysate (5, 15 and 50 ug) from HeLa cells. Antibody: Affinity purified rabbit anti-ARID1A antibody used for WB at 0.04 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
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ARID1A / BAF250 Rabbit anti-Human Polyclonal (aa675-725) Antibody
Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
ARID1A / BAF250 Antibody - Immunohistochemistry of ARID1A in mouse brain tissue with ARID1A antibody at 5 µg/mL.
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ARID1A / BAF250 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
ARID1A / BAF250 Antibody - Anti-ARID1A Antibody (C-Term) at 1:2000 dilution + Jurkat whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 242 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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ARID1A / BAF250 Rabbit anti-Human Polyclonal (aa1930-1964) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
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ARID1A / BAF250 Mouse anti-Human Monoclonal (2035Ca) Antibody
Human
WB
Unconjugated
50 µg/$558
ARID1A / BAF250 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
ARID1A / BAF250 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
ARID1A / BAF250 Antibody - Immunohistochemistry image at a dilution of 1:500 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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ARID1A / BAF250 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
ARID1A / BAF250 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
ARID1A / BAF250 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
ARID1A / BAF250 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
ARID1A / BAF250 Antibody - Immunofluorescence analysis of A549 cells.
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ARID1A / BAF250 Rabbit anti-Mouse Polyclonal Antibody
Mouse
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
ARID1A / BAF250 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using ARID1A Polyclonal Antibody at dilution of 1:80.
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ARID1A / BAF250 Rabbit anti-Human Polyclonal (aa95-108) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ARID1A / BAF250 Antibody - Anti-ARID1A Antibody (C-Term) at 1:2000 dilution + SK-OV-3 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 242 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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ARID1A / BAF250 Rabbit anti-Human Polyclonal (aa1717-1750) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
ARID1A / BAF250 Antibody - Western blot analysis of ARI1A using NIH-3T3 whole cells lysates
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ARID1A / BAF250 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ARID1A / BAF250 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY ARID1A. (Right lane) cDNA for 48 hrs and lysed
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ARID1A / BAF250 Mouse anti-Human Monoclonal (aa1986-2285) (OTI4D1) Antibody
Human
WB
Unconjugated
100 µl/$434
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ARID1A / BAF250 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$412
ARID1A / BAF250 Antibody
Select
ARID1A / BAF250 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
ARID1A / BAF250 Antibody - Detection of Human ARID1A by Western Blot. Samples: Whole cell lysate (5, 15 and 50 ug) from HeLa cells. Antibody: Affinity purified rabbit anti-ARID1A antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Select
ARID1A / BAF250 Rabbit anti-Human Polyclonal (aa750-800) Antibody
Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
ARID1A / BAF250 Antibody - ARID1A antibody Western blot. All lanes: Anti ARID1A at 0.5 ug/ml. Lane 1: SW620 Whole Cell Lysate at 40 ug. Lane 2: HEPG2 Whole Cell Lysate at 40 ug. Predicted band size: 242 kD. Observed band size: 242 kD.
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ARID1A / BAF250 Rabbit anti-Human Polyclonal (aa1021-1053) Antibody
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
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ARID1A / BAF250 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC-P
Unconjugated
100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).