ARHGEF2 / GEF-H1

Rho/Rac guanine nucleotide exchange factor (GEF) 2

Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

ARHGEF2 / GEF-H1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (1)

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ARHGEF2 / GEF-H1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116454

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108.1 kDa

Price:

100 µg/$494

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Human ARHGEF2 / GEF-H1 Protein (Recombinant GST) (Full Length) - LS-G31515

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

131.12 kDa

Price:

2 µg/$439

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Human ARHGEF2 / GEF-H1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68262

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108.1 kDa

Price:

20 µg/$1,107

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Human ARHGEF2 / GEF-H1 Protein (Recombinant GST, N-terminus) (aa590-690) - LS-G61022

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ARHGEF2 / GEF-H1 Protein (Recombinant GST, N-terminus) (aa860-959) - LS-G61023

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ARHGEF2 / GEF-H1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81768

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108.1 kDa

Price:

20 µg/$150

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