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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ARHGEF2 / GEF-H1

Rho/Rac guanine nucleotide exchange factor (GEF) 2

Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.

Gene Name: Rho/Rac guanine nucleotide exchange factor (GEF) 2
Synonyms: ARHGEF2, GEF H1, GEFH1, GEF-H1, LFP40, Microtubule-regulated Rho-GEF, KIAA0651, GEF, p40
Target Sequences: NM_004723 NP_004714.2 Q92974

Filtered By: None
Target
ARHGEF2 / GEF-H1 (27)
Reactivity
Human (25)
Mouse (13)
Rat (10)
Bovine (2)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (2)
Hamster (1)
Monkey (1)
Pig (3)
Rabbit (2)
Application
IHC (10)
IHC-Fr (2)
IHC-P (3)
WB (22)
ELISA (8)
IF (5)
IP (6)
Peptide-ELISA (3)
Host
rabbit (24)
mouse (2)
sheep (1)
Isotype
IgG (15)
IgG1 (2)
Clonality
monoclonal mc (3)
polyclonal pc (24)
Clone
B4/7 (2)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (24)
Epitope
aa694-743 (4)
820-900 aa (2)
Pro881 (2)
aa625-675 (2)
360-440 aa, Internal (1)
C-Terminus (1)
Internal (1)
aa2-447 (1)
aa383-432 (1)
aa425-470 (1)
aa633-805 (1)
aa675-725 (1)
aa850-900 (1)
aa851-900 (1)
pSer885 (1)
Publications
No (27)
Showing 1-25 of 27 results

ARHGEF2 / GEF-H1 Antibody (aa383-432) IHC-plus™ LS-B9262
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-ARHGEF2 / GEF-H1 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Western blot analysis of lysates from RAW264.7 cells, using ARHGEF2 Antibody. The lane on the right is blocked with the synthesized peptide.
Anti-ARHGEF2 / GEF-H1 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Western blot analysis of lysates from RAW264.7 cells, using ARHGEF2 Antibody. The lane on the right is blocked with the synthesized peptide.

ARHGEF2 / GEF-H1 Antibody LS-C38890
Rabbit Monoclonal (IgG) to Human ARHGEF2 / GEF-H1
Mouse, Rat, Hamster, Human, Monkey
ELISA IP WB
Unconjugated
100µl  $530.00

ARHGEF2 / GEF-H1 Antibody (clone B4/7) LS-C123673
Mouse Monoclonal [clone B4/7] (IgG1) to Dog ARHGEF2 / GEF-H1
Dog, Human
ELISA IF IHC IHC-Fr IP WB
Unconjugated
100µg  $950.00

ARHGEF2 / GEF-H1 Antibody (aa625-675) LS-C288697
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Rabbit, Guinea pig, Bovine, Pig, Human
IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human GEF-H1 by Immunohistochemistry. Sample: FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-GEF-H1 used at a dilution of 1:1000 (1 Detection: DAB.
Detection of Human GEF-H1 by Immunohistochemistry. Sample: FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-GEF-H1 used at a dilution of 1:1000 (1 Detection: DAB.

ARHGEF2 / GEF-H1 Antibody (clone B4/7) LS-C140071
Mouse Monoclonal [clone B4/7] (IgG1) to Dog ARHGEF2 / GEF-H1
Dog, Human
IF IHC IHC-Fr IP WB
Unconjugated
100µg  $620.00

ARHGEF2 / GEF-H1 Antibody (aa625-675) LS-C286780
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Rabbit, Guinea pig, Bovine, Pig, Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human GEF-H1 by Immunohistochemistry. Sample: FFPE section of human stomach adenocarcinoma. Antibody: Affinity purified rabbit anti-GEF-H1 used at a dilution of 1:250.
Detection of Human GEF-H1 by Immunohistochemistry. Sample: FFPE section of human stomach adenocarcinoma. Antibody: Affinity purified rabbit anti-GEF-H1 used at a dilution of 1:250.

ARHGEF2 / GEF-H1 Antibody (820-900 aa) LS-C380996
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

ARHGEF2 / GEF-H1 Antibody (360-440 aa, Internal) LS-C384335
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

ARHGEF2 / GEF-H1 Antibody (aa2-447) LS-C140489
Sheep Polyclonal (IgG) to Mouse ARHGEF2 / GEF-H1
Mouse
IF IP WB
Unconjugated
250µg  $355.00
Western blot of anti-Lfc antibody on HEK-293 cell transfected with vector alone (1), lfc-short (2) and lfc-long (3).
Western blot of anti-Lfc antibody on HEK-293 cell transfected with vector alone (1), lfc-short (2) and lfc-long (3).

ARHGEF2 / GEF-H1 Antibody (aa425-470) LS-C313813
Rabbit Polyclonal to Human ARHGEF2 / GEF-H1
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $345.00

ARHGEF2 / GEF-H1 Antibody LS-C404553
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human lung cancer using ARHGEF2 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human lung cancer using ARHGEF2 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human lung cancer using ARHGEF2 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human lung cancer using ARHGEF2 Polyclonal Antibody at dilution of 1:30.

ARHGEF2 / GEF-H1 Antibody LS-C665807
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Human
ELISA WB
Unconjugated
100µg  $375.00

ARHGEF2 / GEF-H1 Antibody (aa633-805) LS-C348825
Rabbit Polyclonal to Human ARHGEF2 / GEF-H1
Human
ELISA WB
Unconjugated
100µl 1mg/ml  $255.00
Western blot of ARHGEF2 / GEF-H1 antibody
Western blot of ARHGEF2 / GEF-H1 antibody

ARHGEF2 / GEF-H1 Antibody (820-900 aa) LS-C384336
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Mouse, Rat, Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Lfc antibody
Western blot of Lfc antibody
Western blot of Lfc antibody
Western blot of Lfc antibody

ARHGEF2 / GEF-H1 Antibody (aa851-900) LS-C118031
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Mouse, Rat, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from NIH/3T3 cells, using Rho/Rac Guanine Nucleotide Exchange Factor 2 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from NIH/3T3 cells, using Rho/Rac Guanine Nucleotide Exchange Factor 2 Antibody. The lane on the right is blocked with the synthesized peptide.

ARHGEF2 / GEF-H1 Antibody (phospho-Ser885) LS-C199541
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Mouse, Rat, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from HeLa cells treated with TSA 400nM 24H and Jurkat cells treated with forskolin 40nM 30', using Rho/Rac Guanine Nucleotide Exchange Factor 2 (Phospho-Ser885) Antibody. The lane on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HeLa cells treated with TSA 400nM 24H and Jurkat cells treated with forskolin 40nM 30', using Rho/Rac Guanine Nucleotide Exchange Factor 2 (Phospho-Ser885) Antibody. The lane on the right is blocked with the phospho peptide.

ARHGEF2 / GEF-H1 Antibody LS-C747643
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Mouse, Human
IHC
Unconjugated
50µl  $235.00

ARHGEF2 / GEF-H1 Antibody (Pro881) LS-C191900
Rabbit Polyclonal to Mouse ARHGEF2 / GEF-H1
Mouse
WB
Unconjugated
100µl  $345.00

ARHGEF2 / GEF-H1 Antibody (aa694-743) LS-C135579
Rabbit Polyclonal to Human ARHGEF2 / GEF-H1
Human
WB
Unconjugated
50µg  $365.00
ARHGEF2 / GEF-H1 antibody Western blot of Placenta lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ARHGEF2 / GEF-H1 antibody Western blot of Placenta lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ARHGEF2 / GEF-H1 Antibody (aa694-743, HRP) LS-C466507
Rabbit Polyclonal to Human ARHGEF2 / GEF-H1
Human, Chimpanzee, Gibbon
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
ARHGEF2 / GEF-H1 antibody Western blot of Placenta lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ARHGEF2 / GEF-H1 antibody Western blot of Placenta lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ARHGEF2 / GEF-H1 Antibody (Pro881) LS-C176996
Rabbit Polyclonal to Human ARHGEF2 / GEF-H1
Mouse, Rat, Human
WB
Unconjugated
100µl  $345.00
Western blot of ARHGEF2 (P881) pAb in extracts from NIH cells.
Western blot of ARHGEF2 (P881) pAb in extracts from NIH cells.

ARHGEF2 / GEF-H1 Antibody (C-Terminus) LS-C358906
Rabbit Polyclonal to Human ARHGEF2 / GEF-H1
Mouse, Dog, Rat, Pig, Human
WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Western blot analysis of GEF H1 expression in HeLa (A); Jurkat (B); NIH3T3 (C) whole cell lysates.
Western blot analysis of GEF H1 expression in HeLa (A); Jurkat (B); NIH3T3 (C) whole cell lysates.

ARHGEF2 / GEF-H1 Antibody (Internal) LS-C353142
Rabbit Polyclonal to Human ARHGEF2 / GEF-H1
Mouse, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of GEF H1 expression in HeLa (A); NIH3T3 (B); H9C2 (C) whole cell lysates.
Western blot analysis of GEF H1 expression in HeLa (A); NIH3T3 (B); H9C2 (C) whole cell lysates.

ARHGEF2 / GEF-H1 Antibody (aa850-900) LS-C288698
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Human
IP
Unconjugated
100µl 1mg/ml  $395.00

ARHGEF2 / GEF-H1 Antibody (aa675-725) LS-C288699
Rabbit Polyclonal (IgG) to Human ARHGEF2 / GEF-H1
Human
IP
Unconjugated
100µl 1mg/ml  $395.00
Showing 1-25 of 27 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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